Endocannabinoid structure–activity relationships for interaction at the cannabinoid receptors
PH Reggio - Prostaglandins, Leukotrienes and Essential Fatty Acids …, 2002 - Elsevier
Anandamide (N-arachidonoylethanolamine) was the first ligand to be identified as an
endogenous ligand of the G-protein coupled cannabinoid CB1 receptor. Subsequently, two …
endogenous ligand of the G-protein coupled cannabinoid CB1 receptor. Subsequently, two …
Conformational requirements for endocannabinoid interaction with the cannabinoid receptors, the anandamide transporter and fatty acid amidohydrolase
PH Reggio, H Traore - Chemistry and Physics of Lipids, 2000 - Elsevier
Anandamide (N-arachidonoylethanolamine) has been identified as an endogenous ligand
of the G-protein coupled cannabinoid CB1 receptor. Recent studies have postulated the …
of the G-protein coupled cannabinoid CB1 receptor. Recent studies have postulated the …
Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown
PH Reggio - Current medicinal chemistry, 2010 - ingentaconnect.com
The cannabinoid CB1 and CB2 receptors are Class AG protein-coupled receptors (GPCRs).
While many Class A GPCRs have endogenous ligands that are hydrophilic cations (eg, the …
While many Class A GPCRs have endogenous ligands that are hydrophilic cations (eg, the …
Natural and synthetic endocannabinoids and their structure-activity relationships
SL Palmer, AD Khanolkar… - Current pharmaceutical …, 2000 - ingentaconnect.com
The identification of arachidonylethanolamide (anandamide, AEA) as an endogenous
cannabinoid has been an important development in cannabinoid research which has led to …
cannabinoid has been an important development in cannabinoid research which has led to …
Novel selective and metabolically stable inhibitors of anandamide cellular uptake
G Ortar, A Ligresti, L De Petrocellis, E Morera… - Biochemical …, 2003 - Elsevier
Novel aromatic analogues of N-oleoylethanolamine and N-arachidonoylethanolamine
(anandamide, AEA) were synthesized and, based on the capability of similar compounds to …
(anandamide, AEA) were synthesized and, based on the capability of similar compounds to …
N-acyl-dopamines: novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo
T Bisogno, D Melck, MY Bobrov… - Biochemical …, 2000 - portlandpress.com
We reported previously that synthetic amides of polyunsaturated fatty acids with bioactive
amines can result in substances that interact with proteins of the endogenous cannabinoid …
amines can result in substances that interact with proteins of the endogenous cannabinoid …
Metabolism of endocannabinoids and related N‐acylethanolamines: Canonical and alternative pathways
N Ueda, K Tsuboi, T Uyama - The FEBS journal, 2013 - Wiley Online Library
Endocannabinoids are endogenous ligands of the cannabinoid receptors CB 1 and CB 2.
Two arachidonic acid derivatives, arachidonoylethanolamide (anandamide) and 2 …
Two arachidonic acid derivatives, arachidonoylethanolamide (anandamide) and 2 …
Inactivation and biotransformation of the endogenous cannabinoids anandamide and 2-arachidonoylglycerol
ML Yates, EL Barker - Molecular pharmacology, 2009 - ASPET
The cannabinoid field is currently an active research area. Anandamide (AEA) and 2-
arachidonoylglycerol (2-AG) are the most characterized endogenous cannabinoids (also …
arachidonoylglycerol (2-AG) are the most characterized endogenous cannabinoids (also …
Organized trafficking of anandamide and related lipids
ML Yates, EL Barker - Vitamins & hormones, 2009 - Elsevier
N‐arachidonylethanolamide (anandamide or AEA) is an endogenous long‐chain fatty acid
ethanolamide with activity at both the cannabinoid 1 (CB 1) and cannabinoid 2 (CB 2) …
ethanolamide with activity at both the cannabinoid 1 (CB 1) and cannabinoid 2 (CB 2) …
Regulation by cannabinoid receptors of anandamide transport across the blood-brain barrier and through other endothelial cells
M Maccarrone, A Fiori, M Bari, F Granata… - Thrombosis and …, 2006 - thieme-connect.com
The endocannabinoid anandamide (AEA) has many neurovascular activities. However, it is
not yet clear how AEA can be metabolized at the neurovascular interface, and how it can …
not yet clear how AEA can be metabolized at the neurovascular interface, and how it can …
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