Liver cell types derived from induced pluripotent stem cells (iPSCs) share the potential to
investigate development, toxicity, as well as genetic and infectious disease in ways currently …

“Liver medicine” refers to all diagnostic and treatment strategies of diseases and conditions
that cause liver failure directly or indirectly. Despite significant advances in the field of liver …

Organoid cultures have emerged as an alternative in vitro system to recapitulate tissues in a
dish. While mouse models and cell lines have furthered our understanding of liver biology …

Organoids are three-dimensional culture systems in which adult stem cells and their
progeny grow and represent the native physiology of the cells in vivo. Organoids have been …

A growing number of in vitro hepatic models exist to study human genetics, liver biology,
disease modeling and drug development and range from 2D hepatocytes to 3D multi …

The organoid model represents a major breakthrough in cell biology that has revolutionised
biomedical research. Organoids are 3D physiological in vitro structures that recapitulate …

Liver transplantation is the most common treatment for patients suffering from liver failure
that is caused by congenital diseases, infectious agents, and environmental factors. Despite …

Liver diseases negatively impact the quality of life and survival of patients, and often require
liver transplantation in cases that progress to organ failure. Understanding the cellular and …

The burden of liver diseases is increasing worldwide, with liver transplantation remaining
the only treatment option for end‐stage liver disease. Regenerative medicine holds great …

Background Liver organoid technology holds great promises to be used in large-scale
population-based drug screening and in future regenerative medicine strategies. Recently …