Homozygous or compound heterozygous mutations in the high-temperature requirement A
serine protease 1 gene (HTRA1) cause cerebral autosomal recessive arteriopathy with …

Aims Cerebral small vessel disease (SVD) is the leading cause of vascular dementia.
Although the most of cases are sporadic, familial monogenic causes have been identified in …

HTRA1 disorder is a phenotypic spectrum in which some individuals have few to no
symptoms and others manifest with the more severe CARASIL (cerebral autosomal …

Cerebral autosomal recessive arteriopathy with subcortical infarcts and
leukoencephalopathy (CARASIL) was previously considered a rare, early-onset recessive …

Cerebral small vessel disease (SVD) is a mostly sporadic disorder leading to stroke and
cognitive impairment. In very rare cases homozygous mutations of the HTRA1 gene (high …

Cerebral small vessel disease (SVD) is recognized to be the leading cause of vascular
dementia. Although the most cases are sporadic, familial monogenic causes have been …

Objective: Mutations in the high-temperature requirement A serine peptidase 1 (HTRA1)
gene were studied in a Chinese family with cerebral autosomal recessive arteriopathy with …

Objective: To elucidate the molecular mechanism of mutant HTRA1-dependent cerebral
small vessel disease in heterozygous individuals. Methods: We recruited 113 unrelated …

Background The genetic cause of cerebral autosomal recessive arteriopathy with subcortical
infarcts and leukoencephalopathy (CARASIL), which is characterized by ischemic …

Cerebral autosomal recessive arteriopathy with subcortical infarcts and
leukoencephalopathy (CARASIL) is an extremely rare hereditary cerebral small vessel …