The roles and targeting options of TRIM family proteins in tumor

Y Zhang, W Zhang, L Zheng, Q Guo - Frontiers in Pharmacology, 2022 - frontiersin.org
Tripartite motif (TRIM) containing proteins are a class of E3 ubiquitin ligases, which are
critically implicated in the occurrence and development of tumors. They can function through …

The translational values of TRIM family in pan-cancers: From functions and mechanisms to clinics

G Zhao, C Liu, X Wen, G Luan, L Xie, X Guo - Pharmacology & …, 2021 - Elsevier
Cancer is the second leading cause of human death across the world. Tripartite motif (TRIM)
family, with E3 ubiquitin ligase activities in majority of its members, is reported to be involved …

TRIM family contribute to tumorigenesis, cancer development, and drug resistance

N Huang, X Sun, P Li, X Liu, X Zhang, Q Chen… - … Hematology & Oncology, 2022 - Springer
The tripartite-motif (TRIM) family represents one of the largest classes of putative single
protein RING-finger E3 ubiquitin ligases. TRIM family is involved in a variety of cellular …

[HTML][HTML] E3 ubiquitin ligase-dependent regulatory mechanism of TRIM family in carcinogenesis

G Zhang, Y Zhang, L Chen, L Liu, X Gao - Cancer Insight, 2023 - anserpress.org
Tripartite motif-containing (TRIM) proteins consist of over 80 proteins, the majority of which
exhibit E3 ubiquitin ligase activity. E3 ligases have a critical role in various cellular …

The TRIM proteins in cancer: from expression to emerging regulatory mechanisms

A Mohammadi, MS Pour Abbasi, S Khorrami… - Clinical and …, 2022 - Springer
New clinical evidence suggests that dysregulation of the ubiquitin-mediated destruction of
tumor suppressors or oncogene products is probably engaged in the etiology of leukemia …

Mutual regulation between TRIM21 and TRIM8 via K48-linked ubiquitination

L Wang, H Li, A Huang, Y Zhao, C Xiao, J Dong, X Liu… - Oncogene, 2023 - nature.com
Tripartite motif (TRIM)-containing proteins, one of the largest subfamilies of the RING type E3
ubiquitin ligases, control important biological processes such as cell apoptosis, autophagy …

[HTML][HTML] Deciphering roles of TRIMs as promising targets in hepatocellular carcinoma: current advances and future directions

J Zhang, Y Zhou, J Feng, X Xu, J Wu, C Guo - Biomedicine & …, 2023 - Elsevier
Tripartite motif (TRIM) family is assigned to RING-finger-containing ligases harboring the
largest number of proteins in E3 ubiquitin ligating enzymes. E3 ubiquitin ligases target the …

TRIM proteins in lung cancer: Mechanisms, biomarkers and therapeutic targets

W Zhan, S Zhang - Life Sciences, 2021 - Elsevier
The tripartite motif (TRIM) family is defined by the presence of a Really Interesting New Gene
(RING) domain, one or two B-box motifs and a coiled-coil region. TRIM proteins play key …

Dissecting the functional role of the TRIM8 protein on cancer pathogenesis

JE Esposito, V De Iuliis, F Avolio, E Liberatoscioli… - Cancers, 2022 - mdpi.com
Simple Summary The tripartite motif (TRIM) gene family is a large group of E3 ubiquitin
ligase proteins that can also have proteasome-independent functions. This review …

Multifaceted roles of TRIM proteins in colorectal carcinoma

W Eberhardt, K Haeussler, U Nasrullah… - International journal of …, 2020 - mdpi.com
Colorectal cancer (CRC) is one of the most frequently diagnosed tumor in humans and one
of the most common causes of cancer-related death worldwide. The pathogenesis of CRC …