Background Elevated adiposity is often posited by medical and public health researchers to
be a risk factor associated with cardiovascular disease, diabetes, and other diseases. These …

Background: Adiposity is a risk factor for type 2 diabetes and cardiovascular disease,
suggesting an important role for adipose tissue in the development of these conditions. The …

Obesity is an important component of the pathophysiology of chronic diseases. Identifying
epigenetic modifications associated with elevated adiposity, including DNA methylation …

Rationale: Previous EWASs (Epigenome-Wide Association Studies) suggest that obesity
may be the cause, not a consequence, of changes in DNA methylation (DNAm). However …

Background The link between DNA methylation, obesity, and adiposity-related diseases in
the general population remains uncertain. Methods and Findings We conducted an …

Most epigenome-wide association studies to date have been conducted in blood. However,
metabolic syndrome is mediated by a dysregulation of adiposity and therefore it is critical to …

Background Obesity is an established risk factor for several common chronic diseases such
as breast and colorectal cancer, metabolic and cardiovascular diseases; however, the …

Background The prevalence of obesity and its related chronic diseases have been
increasing especially in Asian countries. Obesity-related genetic variants have been …

Obesity is associated with increased risk of several diseases and has become epidemic.
Obesity is highly heritable but the genetic variants identified by genome-wide association …

Aim: We conducted a methylome-wide association study to examine associations between
DNA methylation in whole blood and central adiposity and body fat distribution, measured …