Nuclear transcription factors of the NF-κB/Rel family are inhibited by IκB proteins, which
inactivate NF-κB by trapping it in the cell cytoplasm. Phosphorylation of IκBs marks them out …

Pro-inflammatory cytokines activate the transcription factor NF-κB by stimulating the activity
of a protein kinase that phosphorylates IκB, an inhibitor of NF-κB,,,,, at sites that trigger its …

NF-κB is a principal transcriptional regulator of diverse cytokine-mediated processes and is
tightly controlled by the IκB kinase complex (IKK-α/β/γ). IKK-β and IKK-γ are critical for …

Phosphorylation of IκB by the IκB kinase (IKK) complex is a critical step leading to IκB
degradation and activation of transcription factor NF-κB. The IKK complex contains two …

The activation of pro-inflammatory gene programs by nuclear factor-κB (NF-κB) is primarily
regulated through cytoplasmic sequestration of NF-κB by the inhibitor of κB (IκB) family of …

The transcription factor NF-κB coordinates the activation of numerous genes in response to
pathogens and pro-inflammatory cytokines, and is, therefore, vital in the development of …

Cytokine-induced activation of the IκB kinases (IKK) IKK-α and IKK-β is a key step involved
in the activation of the NF-κB pathway,,,. Gene-disruption studies of the murine IKK genes …

Activation of the transcription factor nuclear factor kappa B (NF-κB) is controlled by
sequential phosphorylation, ubiquitination, and degradation of its inhibitory subunit IκB. A …

The inhibitor of NF-κB (IκB) family of proteins is believed to regulate NF-κB activity by
cytoplasmic sequestration. We show that in cells depleted of IκBα, IκBβ and IκBε proteins, a …

A large protein complex mediates the phosphorylation of the inhibitor of κB (IκB), which
results in the activation of nuclear factor κB (NF-κB). Two subunits of this complex, IκB kinase …