SMARCA4 deficiency-associated heterochromatin induces intrinsic DNA replication stress and susceptibility to ATR inhibition in lung adenocarcinoma
K Kurashima, H Kashiwagi, I Shimomura, A Suzuki… - NAR …, 2020 - academic.oup.com
The SWI/SNF chromatin remodeling complex regulates transcription through the control of
chromatin structure and is increasingly thought to play an important role in human cancer …
chromatin structure and is increasingly thought to play an important role in human cancer …
SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells
The packaging of DNA into chromatin plays an important role in transcriptional regulation
and nuclear processes. Brahma-related gene-1 SMARCA4 (also known as BRG1), the …
and nuclear processes. Brahma-related gene-1 SMARCA4 (also known as BRG1), the …
[HTML][HTML] Nuclear localization of ISWI ATPase Smarca5 (Snf2h) in mouse
J Vargova, K Vargova, AI Skoultchi… - Frontiers in bioscience …, 2009 - ncbi.nlm.nih.gov
Nucleosome movement is, at least in part, facilitated by ISWI ATPase Smarca5 (Snf2h).
Smarca5 gene inactivation in mouse demonstrated its requirement at blastocyst stage; …
Smarca5 gene inactivation in mouse demonstrated its requirement at blastocyst stage; …
Loss of ISWI ATPase SMARCA5 (SNF2H) in acute myeloid leukemia cells inhibits proliferation and chromatid cohesion
T Zikmund, H Paszekova, J Kokavec, P Kerbs… - International journal of …, 2020 - mdpi.com
ISWI chromatin remodeling ATPase SMARCA5 (SNF2H) is a well-known factor for its role in
regulation of DNA access via nucleosome sliding and assembly. SMARCA5 transcriptionally …
regulation of DNA access via nucleosome sliding and assembly. SMARCA5 transcriptionally …
The recruitment of ACF1 and SMARCA5 to DNA lesions relies on ADP-ribosylation dependent chromatin unfolding
E Pinto Jurado, R Smith, N Bigot… - Molecular biology of …, 2024 - Am Soc Cell Biol
ADP-ribosylation signaling orchestrates the recruitment of various repair actors and
chromatin remodeling processes promoting access to lesions during the early stages of the …
chromatin remodeling processes promoting access to lesions during the early stages of the …
Remodeling and spacing factor 1 (RSF1): a rising star in DNA repair
A Helfricht, H Van Attikum - Epigenomics, 2014 - Taylor & Francis
The Williams syndrome transcription factor (WSTF), also called BAZ1B, was shown to have
kinase activity and was found to phosphorylate histone H2AX on Tyr142. Although WSTF is …
kinase activity and was found to phosphorylate histone H2AX on Tyr142. Although WSTF is …
The novel protein complex with SMARCAD1/KIAA1122 binds to the vicinity of TSS
N Okazaki, S Ikeda, R Ohara, K Shimada… - Journal of molecular …, 2008 - Elsevier
The SMARCAD1/KIAA1122 protein is structurally classified into the SWI2/SNF2 superfamily
of DNA-dependent ATPases that are catalytic subunits of chromatin-remodeling complexes …
of DNA-dependent ATPases that are catalytic subunits of chromatin-remodeling complexes …
Remodelling regulates the heterochromatin of retrotransposons in mouse embryonic stem cells
P Sachs - 2021 - archiv.ub.uni-marburg.de
Chromatin remodellers slide, assemble, eject or edit nucleosomes influencing chromatin
structure, DNA accessibility and transcriptional programmes. The SNF2-like remodeller …
structure, DNA accessibility and transcriptional programmes. The SNF2-like remodeller …
Loss of SMARCA4 Leads to an Impaired Hematopoiesis in Mice
F Modemann, L Ramke, E Erdal, M Schoof, C Göbel… - Blood, 2023 - Elsevier
SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin,
subfamily a) is the central ATPase containing enzyme in the SWI/SNF-(switch/sucrose non …
subfamily a) is the central ATPase containing enzyme in the SWI/SNF-(switch/sucrose non …
SMARCA2/4 degraders relieve the differentiation block in AML via changes in chromatin looping and accessibility
S Aminov, K Pradhan, S Sahu, S Gordon-Mitchell… - Cancer Research, 2024 - AACR
Abstract Acute Myeloid Leukemia (AML) is characterized by the unfettered proliferation and
poor differentiation of myeloid cells causing reduced survival. The mammalian BAF …
poor differentiation of myeloid cells causing reduced survival. The mammalian BAF …