Background: Genomic studies have demonstrated a high frequency of genetic alterations in
components of the SWI/SNF complex including the core subunit SMARCA4. However, the …

The SMARCA4/BRG1 gene product is a component of the SWI‐SNF chromatin‐remodeling
complex and regulates gene expression by disrupting histone‐DNA contacts in an ATP …

Abstract Background: The BAF (SWI/SNF) chromatin remodeling complex comprises of two
mutually exclusive ATPases, SMARCA2 (BRM) and SMARCA4 (BRG1), that affect the …

The human genome encodes millions of regulatory elements, of which only a small fraction
are active within a given cell type. Little is known about the global impact of chromatin …

Collectively, genes encoding subunits of the SWI/SNF (BAF) chromatin remodeling complex
are mutated in 20% of all human cancers, with the SMARCA4 (BRG1) subunit being one of …

Disruption of chromatin organization during replication poses a major challenge to the
maintenance and integrity of genome organization. It creates the need to accurately …

SMARCA2 and SMARCA4 (SMARCA2/4) are paralogs and act as the key enzymatic
subunits in the SWI/SNF complex for chromatin remodeling. However, the role of …

Biological Target. SMARCA2 and SMARCA4 Summary. The SMARCA subgroup of genes
belong to the SWI1/SNF1 family that provide instructions for making chromatin remodeling …

ATP-dependent chromatin remodelers (ADCRs) convert local chromatin structure into both
transcriptional active and repressive state. Recent studies have revealed that ADCRs play …

Proper signalling and repair of DNA double-strand breaks (DSB) is critical to prevent
genome instability and diseases such as cancer. The packaging of DNA into chromatin …