USP3 promotes DNA damage response and chemotherapy resistance through stabilizing and deubiquitinating SMARCA5 in prostate cancer
S Li, S Xiong, Z Li, L Yang, H Yang, Y Xiong, X Zhan… - 2024 - researchsquare.com
The chromatin-remodeling enzyme SMARCA5 plays a key role in DNA-templated events
including transcription, DNA replication, and DNA repair. Loss of function of the SMARCA5 …
including transcription, DNA replication, and DNA repair. Loss of function of the SMARCA5 …
Expression inactivation of SMARCA4 by microRNAs in lung tumors
IF Coira, EE Rufino-Palomares… - Human molecular …, 2015 - academic.oup.com
SMARCA4 is the catalytic subunit of the SWI/SNF chromatin-remodeling complex, which
alters the interactions between DNA and histones and modifies the availability of the DNA …
alters the interactions between DNA and histones and modifies the availability of the DNA …
SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions
SMARCA4 encodes one of two mutually exclusive ATPase subunits in the BRG/BRM
associated factor (BAF) complex that is recruited by transcription factors (TFs) to drive …
associated factor (BAF) complex that is recruited by transcription factors (TFs) to drive …
SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells
P Sachs, D Ding, P Bergmaier, B Lamp… - Nature …, 2019 - nature.com
Endogenous retroviruses (ERVs) can confer benefits to their host but present a threat to
genome integrity if not regulated correctly. Here we identify the SWI/SNF-like remodeler …
genome integrity if not regulated correctly. Here we identify the SWI/SNF-like remodeler …
[HTML][HTML] Smarca2 genetic ablation is phenotypically benign in a safety assessment of tamoxifen-inducible conditional knockout rats
J Maher, N Stagg, G Cain, R Andaya… - Toxicology and Applied …, 2023 - Elsevier
SMARCA2 and SMARCA4 are the ATPases of the SWI/SNF chromatin remodeling complex,
which play a significant role in regulating transcriptional activity and DNA repair in cells …
which play a significant role in regulating transcriptional activity and DNA repair in cells …
[HTML][HTML] The role of ISWI chromatin remodeling complexes in brain development and neurodevelopmental disorders
LR Goodwin, DJ Picketts - Molecular and Cellular Neuroscience, 2018 - Elsevier
Abstract The mammalian ISWI (Imitation Switch) genes SMARCA1 and SMARCA5 encode
the ATP-dependent chromatin remodeling proteins SNF2L and SNF2H. The ISWI proteins …
the ATP-dependent chromatin remodeling proteins SNF2L and SNF2H. The ISWI proteins …
Chromatin structure and function
LN Mishra, C Thiriet, D Vasudevan - Frontiers in Genetics, 2023 - frontiersin.org
Chromatin dynamics influence DNA-dependent processes such as transcription, repair,
replication, and recombination (Hübner and Spector, 2010; Galvani and Thiriet, 2015) …
replication, and recombination (Hübner and Spector, 2010; Galvani and Thiriet, 2015) …
Germline SMARCA4 Deletion as a Driver of Uterine Cancer: An Atypical Presentation
A Navitski, DH Al-Rawi, V Makker, B Weigelt… - JCO Precision …, 2022 - ascopubs.org
The SMARCA4 gene codes for a transcription activator protein of the switch/sucrose-
nonfermenting (SWI/SNF) adenosine triphosphate (ATP)–dependent nucleosome …
nonfermenting (SWI/SNF) adenosine triphosphate (ATP)–dependent nucleosome …
Reshuffling chromatin: how the human chromatin remodeler PBAF recognizes nucleosomes
S Osman - Nature Structural & Molecular Biology, 2022 - nature.com
The genome is wrapped around octamers of histone proteins forming repeating units called
nucleosomes that resemble beads on a string. These structure chromatin, but also present …
nucleosomes that resemble beads on a string. These structure chromatin, but also present …
Structure of human chromatin-remodelling PBAF complex bound to a nucleosome
J Yuan, K Chen, W Zhang, Z Chen - Nature, 2022 - nature.com
DNA wraps around the histone octamer to form nucleosomes, the repeating unit of
chromatin, which create barriers for accessing genetic information. Snf2-like chromatin …
chromatin, which create barriers for accessing genetic information. Snf2-like chromatin …