Background Since a milestone work on Neisseria meningitidis B, Reverse Vaccinology has
strongly enhanced the identification of vaccine candidates by replacing several …

Reverse vaccinology (RV) is a computational approach that aims to identify putative vaccine
candidates in the protein coding genome (proteome) of pathogens. RV has primarily been …

Reverse vaccinology defines the process of antigen discovery starting from genome
information. From its first application to Neisseria meningitidis group B, this approach has …

During the last century, several approaches have been used for the development of
vaccines, going from the immunization with live-attenuated bacteria up to the formulation of …

Reverse Vaccinology (RV) is a widely used approach to identify potential vaccine
candidates (PVCs) by screening the proteome of a pathogen through computational …

Background With advances in reverse vaccinology approaches, a progressive improvement
has been observed in the prediction of putative vaccine candidates. Reverse vaccinology …

Whole genome sequence data are increasingly available for a wide range of human
pathogens. The use of bioinformatic tools allows the comprehensive in silico screening of …

In this article, a framework for an in silico pipeline is presented as a guide to high-throughput
vaccine candidate discovery for eukaryotic pathogens, such as helminths and protozoa …

The conventional approach to vaccine development is based on dissection of the pathogen
using biochemical, immunological and microbiological methods. Although successful in …

Reverse vaccinology (RV) was described at its inception in 2000 as an in silico process that
starts from the genomic sequence of the pathogen and ends with a list of potential protein …