Wnt signalling in kidney diseases: dual roles in renal injury and repair

T Kawakami, S Ren, JS Duffield - The Journal of pathology, 2013 - Wiley Online Library
Wnt signalling is a complex, highly conserved, cell‐to‐cell communication pathway in
multicellular organisms, regulating cell fate, function and phenotype in development, and …

Wnt signaling in kidney development and disease

Y Wang, CJ Zhou, Y Liu - Progress in molecular biology and translational …, 2018 - Elsevier
Wnt signal cascade is an evolutionarily conserved, developmental pathway that regulates
embryogenesis, injury repair, and pathogenesis of human diseases. It is well established …

Wnt signaling in kidney: the initiator or terminator?

P Meng, M Zhu, X Ling, L Zhou - Journal of Molecular Medicine, 2020 - Springer
The kidney is a key organ in the human body that excretes toxins and sustains the water–
electrolyte balance. During embryonic development and disease progression, the kidney …

[HTML][HTML] Wnt/β-catenin signaling in kidney injury and repair: a double-edged sword

D Zhou, RJ Tan, H Fu, Y Liu - Laboratory investigation, 2016 - Elsevier
The Wnt/β-catenin signaling cascade is an evolutionarily conserved, highly complex
pathway that is known to be involved in kidney injury and repair after a wide variety of …

Wnt signaling in kidney development and disease

K Pulkkinen, S Murugan, S Vainio - Organogenesis, 2008 - Taylor & Francis
The Wnt gene family, which encodes secreted growth and differentiation factors, has been
implicated in kidney organogenesis. The Wnts control both ureteric bud development and …

WNT–β-catenin signalling—a versatile player in kidney injury and repair

SJ Schunk, J Floege, D Fliser, T Speer - Nature Reviews Nephrology, 2021 - nature.com
The WNT–β-catenin system is an evolutionary conserved signalling pathway that is of
particular importance for morphogenesis and cell organization during embryogenesis. The …

[HTML][HTML] Wnt/β-catenin signaling and kidney fibrosis

RJ Tan, D Zhou, L Zhou, Y Liu - Kidney international supplements, 2014 - Elsevier
Wnt/β-catenin signaling is an evolutionarily conserved, highly complex, key developmental
pathway that regulates cell fate, organ development, tissue homeostasis, as well as injury …

New insights into the role and mechanism of Wnt/β‐catenin signalling in kidney fibrosis

Y Zuo, Y Liu - Nephrology, 2018 - Wiley Online Library
Wnt/β‐catenin is an evolutionarily conserved, developmental signalling pathway that
regulates embryogenesis, injury repair and pathogenesis of human diseases. Dysregulated …

Coordination of kidney organogenesis by Wnt signaling

K Halt, S Vainio - Pediatric nephrology, 2014 - Springer
Several Wnt proteins are expressed in the embryonic kidney during various stages of
development. Gene knockout models and ex vivo studies have provided strong evidence …

Wnt/β-catenin in acute kidney injury and progression to chronic kidney disease

T Huffstater, WD Merryman, LS Gewin - Seminars in nephrology, 2020 - Elsevier
Acute kidney injury (AKI) portends a poor clinical prognosis and increases the risk for the
development of chronic kidney disease (CKD). Currently, there are no therapies to treat AKI …