[HTML][HTML] An integrated view on vascular dysfunction in Alzheimer's disease

J Klohs - Neurodegenerative Diseases, 2020 - karger.com
Background: Cerebrovascular disease is a common comorbidity in patients with Alzheimer's
disease (AD). It is believed to contribute additively to the cognitive impairment and to lower …

The role of neurovascular system in neurodegenerative diseases

A Ahmad, V Patel, J Xiao, MM Khan - Molecular neurobiology, 2020 - Springer
The neurovascular system (NVS), which consisted of neurons, glia, and vascular cells, is a
functional and structural unit of the brain. The NVS regulates blood-brain barrier (BBB) …

Vascular dysfunction in Alzheimer's disease: a prelude to the pathological process or a consequence of it?

K Govindpani, LG McNamara, NR Smith… - Journal of clinical …, 2019 - mdpi.com
Alzheimer's disease (AD) is the most prevalent form of dementia. Despite decades of
research following several theoretical and clinical lines, all existing treatments for the …

Neurovascular mechanisms of Alzheimer's neurodegeneration

BV Zlokovic - Trends in neurosciences, 2005 - cell.com
In contrast to traditional neuroncentric views of Alzheimer's disease (AD), recent findings
indicate that neurovascular dysfunction contributes to cognitive decline and …

Cerebrovascular phenotypes in mouse models of Alzheimer's disease

JI Szu, A Obenaus - Journal of Cerebral Blood Flow & …, 2021 - journals.sagepub.com
Alzheimer's disease (AD) is a devastating neurological degenerative disorder and is the
most common cause of dementia in the elderly. Clinically, AD manifests with memory and …

Microvascular alterations in Alzheimer's disease

J Steinman, HS Sun, ZP Feng - Frontiers in cellular neuroscience, 2021 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder associated with continual decline
in cognition and ability to perform routine functions such as remembering familiar places or …

Blood-brain barrier dysfunction and the pathogenesis of Alzheimer's disease

Y Yamazaki, T Kanekiyo - International journal of molecular sciences, 2017 - mdpi.com
Brain capillary endothelial cells form the blood-brain barrier (BBB), which is covered with
basement membranes and is also surrounded by pericytes and astrocyte end-feet in the …

Inflammatory process in Alzheimer's Disease

MA Meraz-Ríos, D Toral-Rios… - Frontiers in integrative …, 2013 - frontiersin.org
Alzheimer Disease (AD) is a neurodegenerative disorder and the most common form of
dementia. Histopathologically is characterized by the presence of two major hallmarks, the …

Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease

AP Sagare, RD Bell… - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Neurovascular dysfunction is an integral part of Alzheimer disease (AD). Changes in the
brain vascular system may contribute in a significant way to the onset and progression of …

[HTML][HTML] The blood-brain barrier in Alzheimer's disease

E Zenaro, G Piacentino, G Constantin - Neurobiology of disease, 2017 - Elsevier
Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by the
pathological accumulation of amyloid beta (Aβ) peptides and neurofibrillary tangles …