To match the metabolic demands of the brain, mechanisms have evolved to couple neuronal
activity to vasodilation, thus increasing local cerebral blood flow and delivery of oxygen and …

Alzheimer's disease has various potential etiologies, all culminating in the accumulation of
beta-amyloid derivatives and significant cognitive decline. Vascular-related pathology is one …

In adult brain, new neurons are generated throughout adulthood in the subventricular zone
and the dentate gyrus; this process is commonly known as adult neurogenesis. The …

Alzheimer's disease/senile dementia of the Alzheimer type (AD/SDAT) is the most common
neuropathologic substrate of dementia. It is characterized by synapse loss (predominantly …

Alzheimer's disease (AD) has been recently associated with vascular risk factors. β-amyloid
peptides (AβP), the main component of senile plaques typical of AD, circulate in soluble …

In recent years there has been increased interest in whether vascular disease contributes to
Alzheimer's disease (AD). This review considers how modifiable risk factors such as …

Components of the neurovascular unit (NVU) establish dynamic crosstalk that regulates
cerebral blood flow and maintain brain homeostasis. Here, we describe accumulating …

Cerebral amyloid angiopathy (CAA) is frequently observed in Alzheimer's disease (AD) and
is characterized by deposition of amyloid beta (Aβ) in leptomeningeal and cortical brain …

Cerebrovascular dysfunction contributes to the cognitive decline and dementia in
Alzheimer's disease (AD), and may precede cerebral amyloid angiopathy and brain …

The major neuropathological lesions defining Alzheimer's disease (AD) include
neurofibrillary tangles and amyloid plaques, which are mainly composed of abnormally …