[HTML][HTML] YB-1 is a transcription/translation factor that orchestrates the oncogenome by hardwiring signal transduction to gene expression

J Wu, AL Stratford, A Astanehe… - Translational …, 2007 - ncbi.nlm.nih.gov
Abstract The Y-box Binding Protein-1 (YB-1) is a highly conserved oncogenic transcription/
translation factor that is expressed in cancers affecting adults and children. It is now believed …

YB-1: oncoprotein, prognostic marker and therapeutic target?

A Lasham, CG Print, AG Woolley, SE Dunn… - Biochemical …, 2013 - portlandpress.com
Hanahan and Weinberg have proposed the 'hallmarks of cancer'to cover the biological
changes required for the development and persistence of tumours [Hanahan and Weinberg …

YB-1, the E2F pathway, and regulation of tumor cell growth

A Lasham, W Samuel, H Cao, R Patel… - Journal of the …, 2012 - academic.oup.com
Background Y-box binding factor 1 (YB-1) has been associated with prognosis in many
tumor types. Reduced YB-1 expression inhibits tumor cell growth, but the mechanism is …

[HTML][HTML] YB-1 as an oncoprotein: functions, regulation, post-translational modifications, and targeted therapy

Q Yin, M Zheng, Q Luo, D Jiang, H Zhang, C Chen - Cells, 2022 - mdpi.com
Y box binding protein 1 (YB-1) is a protein with a highly conserved cold shock domain (CSD)
that also belongs to the family of DNA-and RNA-binding proteins. YB-1 is present in both the …

YB-1 transforms human mammary epithelial cells through chromatin remodeling leading to the development of basal-like breast cancer

AH Davies, KM Reipas, MR Pambid, R Berns… - Stem …, 2014 - academic.oup.com
There is growing evidence that cancer-initiation could result from epigenetic changes. Y-box
binding protein-1 (YB-1) is a transcription/translation factor that promotes the formation of …

[HTML][HTML] Role of Y Box Protein-1 in cancer: As potential biomarker and novel therapeutic target

PK Maurya, A Mishra, BS Yadav, S Singh… - Journal of …, 2017 - ncbi.nlm.nih.gov
The Y-box binding protein (YB-1) is known to be a multifunctional transcription and
translation factor during expression of several proteins. It is a vital oncoprotein that regulates …

[HTML][HTML] Translational activation of snail1 and other developmentally regulated transcription factors by YB-1 promotes an epithelial-mesenchymal transition

V Evdokimova, C Tognon, T Ng, P Ruzanov, N Melnyk… - Cancer cell, 2009 - cell.com
Increased expression of the transcription/translation regulatory protein Y-box binding protein-
1 (YB-1) is associated with cancer aggressiveness, particularly in breast carcinoma. Here …

Y-box binding protein 1–a prognostic marker and target in tumour therapy

C Kosnopfel, T Sinnberg, B Schittek - European journal of cell biology, 2014 - Elsevier
Y-box binding protein 1 (YB-1) is a multifunctional protein involved in various cellular
processes including both transcriptional and translational regulation of target gene …

Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR/STAT3 pathway and suppresses tumor growth in mice

C Lee, J Dhillon, MYC Wang, Y Gao, K Hu, E Park… - Cancer research, 2008 - AACR
The Y-box binding protein-1 (YB-1) is a transcription/translation factor that is highly
expressed in primary breast tumors where it is consistently associated with poor survival. It …

[HTML][HTML] YB-1 as a potential target in cancer therapy

H Lage, P Surowiak, PS Holm - Der Pathologe, 2008 - Springer
The 42-kDa multifunctional cellular protein Y-box protein 1 (YB-1) is expressed in various
cancers. It is localized in the cytoplasm as well as in the nucleus. In particular, YB-1 is …