The neuropathology of septic shock

T Sharshar, D Annane, GL de la Gradmaison… - Brain …, 2004 - Wiley Online Library
The neuropathological correlates of encephalopathy and autonomic dysfuction in septic
shock are unclear. We performed post mortem analysis of 5 brain areas susceptible to …

Neuroanatomy and physiology of brain dysfunction in sepsis

A Mazeraud, Q Pascal, F Verdonk… - Clinics in chest …, 2016 - chestmed.theclinics.com
Sepsis-associated encephalopathy (SAE), a major complication of sepsis, is characterized
by impaired consciousness, including delirium and coma. Additionally SAE associates with …

Progress in clinical neurosciences: sepsis-associated encephalopathy: evolving concepts

JX Wilson, GB Young - Canadian Journal of Neurological Sciences, 2003 - cambridge.org
Systemic sepsis commonly produces brain dysfunction, sepsis-associated encephalopathy,
which can vary from a transient, reversible encephalopathy to irreversible brain damage …

Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock

T Sharshar, F Gray, GL de la Grandmaison… - The Lancet, 2003 - thelancet.com
Background Results of experimental and clinical studies have shown that septic shock is
associated with cardiovascular autonomic failure. Thus, we aimed to investigate the …

Brain lesions in septic shock: a magnetic resonance imaging study

T Sharshar, R Carlier, F Bernard, C Guidoux… - Intensive care …, 2007 - Springer
Background Understanding of sepsis-induced brain dysfunction remains poor, and relies
mainly on data from animals or post-mortem studies in patients. The current study provided …

[HTML][HTML] Science review: The brain in sepsis–culprit and victim

T Sharshar, NS Hopkinson, D Orlikowski, D Annane - Critical care, 2004 - Springer
On one side, brain dysfunction is a poorly explored complication of sepsis. On the other side,
brain dysfunction may actively contribute to the pathogenesis of sepsis. The current review …

Systemic inflammation induces apoptosis with variable vulnerability of different brain regions

A Semmler, T Okulla, M Sastre… - Journal of chemical …, 2005 - Elsevier
During severe sepsis several immunological defence mechanisms initiate a cascade of
inflammatory events leading to multi-organ failure including septic encephalopathy and …

The encephalopathy in sepsis

S Siami, D Annane, T Sharshar - Critical care clinics, 2008 - Elsevier
Brain dysfunction is a severe complication of sepsis with an incidence ranging from 9% to
71% that is associated with increased morbidity and mortality. Its diagnosis relies mainly on …

[HTML][HTML] Septic encephalopathy

M Ziaja - Current neurology and neuroscience reports, 2013 - Springer
Every year, more cases of sepsis appear in intensive care units. The most frequent
complication of sepsis is septic encephalopathy (SE), which is also the essential …

[HTML][HTML] Understanding brain dysfunction in sepsis

R Sonneville, F Verdonk, C Rauturier, IF Klein… - Annals of intensive …, 2013 - Springer
Sepsis often is characterized by an acute brain dysfunction, which is associated with
increased morbidity and mortality. Its pathophysiology is highly complex, resulting from both …