Bone metastases are a common occurrence in several malignancies, including breast,
prostate, and lung. Once established in bone, tumors are responsible for significant …

Breast cancer patients with advanced disease exhibit bone metastases, leading to the
formation of osteolytic lesions for which the only currently available treatments are palliative …

Current in vivo models for investigating human primary bone tumors and cancer metastasis
to the bone rely on the injection of human cancer cells into the mouse skeleton. This …

Bone metastases cause significant morbidity and mortality in late-stage breast cancer
patients and are currently considered incurable. Investigators rely on translational models to …

Bone is one of the most common and most dangerous sites for metastatic growth across
cancer types, and bone metastasis remains incurable. Unfortunately, the processes by …

More than 80% of patients with advanced prostate cancer (PCa) experience bone
metastasis, which negatively impacts overall survival and patient quality of life. Various …

Although the current murine model of bone metastasis using intracardiac (IC) injection
successfully recapitulates the process of bone metastasis, further progress in the study of …

Metastasis is the leading cause of cancer-related death and drives patient morbidity as well
as healthcare costs. Bone is the primary site of metastasis for several cancers—breast and …

Once tumor cells metastasize to the bone, the prognosis for prostate cancer patients is
generally very poor. The mechanisms involved in bone metastasis, however, remain elusive …

Breast cancer frequently metastasizes to bone, where it takes a significant toll on quality of
life. Models of bone metastasis are needed in order to better understand the process of bone …