Inhibition of porcine liver carboxylesterase by phosphorylated flavonoids
We have recently synthesized a series of phosphorylated flavonoids and identified some of
them as potent inhibitors of pancreatic cholesterol esterase (CEase) with excellent selectivity …
them as potent inhibitors of pancreatic cholesterol esterase (CEase) with excellent selectivity …
Synthesis and biological evaluation of phosphorylated flavonoids as potent and selective inhibitors of cholesterol esterase
Y Wei, AY Peng, B Wang, L Ma, G Peng, Y Du… - European Journal of …, 2014 - Elsevier
A series of phosphorylated flavonoids were synthesized and investigated in vitro as
inhibitors of pancreatic cholesterol esterase (CEase) and acetylcholinesterase (AChE). The …
inhibitors of pancreatic cholesterol esterase (CEase) and acetylcholinesterase (AChE). The …
A new synthesis of fully phosphorylated flavones as potent pancreatic cholesterol esterase inhibitors
G Peng, Y Du, Y Wei, J Tang, AY Peng… - Organic & Biomolecular …, 2011 - pubs.rsc.org
Five flavones possessing one to four phenolic groups were fully phosphorylated efficiently
and the obtained compounds showed excellent pancreatic cholesterol esterase (CEase) …
and the obtained compounds showed excellent pancreatic cholesterol esterase (CEase) …
Phenolic extracts from various Algerian plants as strong inhibitors of porcine liver carboxylesterase
A Djeridane, M Yousfi, B Nadjemi… - Journal of Enzyme …, 2006 - Taylor & Francis
Carboxylesterases (CE), expressed at high levels in human liver and intestine, are thought
to detoxify xenobiotics. The goal of this study was to study the effect of phenolic compounds …
to detoxify xenobiotics. The goal of this study was to study the effect of phenolic compounds …
Phosphaisocoumarins as a new class of potent inhibitors for pancreatic cholesterol esterase
B Li, B Zhou, H Lu, L Ma, AY Peng - European journal of medicinal …, 2010 - Elsevier
Due to the importance of pancreatic cholesterol esterase (CEase) as a potential target in
atherosclerosis and for the development of hypocholesterolemic agents, there are …
atherosclerosis and for the development of hypocholesterolemic agents, there are …
Isocoumarin-based inhibitors of pancreatic cholesterol esterase
JJ Heynekamp, LA Hunsaker, TA Vander Jagt… - Bioorganic & medicinal …, 2008 - Elsevier
Pancreatic cholesterol esterase (CEase), which is secreted from the exocrine pancreas, is a
serine hydrolase that aids in the bile salt-dependent hydrolysis of dietary cholesteryl esters …
serine hydrolase that aids in the bile salt-dependent hydrolysis of dietary cholesteryl esters …
Benzoflavones as cholesterol esterase inhibitors: Synthesis, biological evaluation and docking studies
Abstract A library of forty 7, 8-benzoflavone derivatives was synthesized and evaluated for
their inhibitory potential against cholesterol esterase (CEase). Among all the synthesized …
their inhibitory potential against cholesterol esterase (CEase). Among all the synthesized …
Characterization and structure-activity relationship studies of flavonoids as inhibitors against human carboxylesterase 2
Human carboxylesterases (hCEs) are key enzymes from the serine hydrolase superfamily.
Among all identified hCEs, human carboxylesterase 2 (hCE2) plays crucial roles in the …
Among all identified hCEs, human carboxylesterase 2 (hCE2) plays crucial roles in the …
Discovery of natural pentacyclic triterpenoids as potent and selective inhibitors against human carboxylesterase 1
PF Song, YD Zhu, HY Ma, YN Wang, DD Wang… - Fitoterapia, 2019 - Elsevier
Abstract Human carboxylesterase 1 (CES1), primarily expressed in the liver and adipocytes,
is responsible for the hydrolysis of endogenous esters (such as cholesteryl esters and …
is responsible for the hydrolysis of endogenous esters (such as cholesteryl esters and …
Structure-activity relationships of pentacyclic triterpenoids as potent and selective inhibitors against human carboxylesterase 1
Human carboxylesterase 1 (hCE1), one of the most important serine hydrolases distributed
in liver and adipocytes, plays key roles in endobiotic homeostasis and xenobiotic …
in liver and adipocytes, plays key roles in endobiotic homeostasis and xenobiotic …