Liver plays a central role in xenobiotics metabolism, thus affecting the in vivo disposition and
therapeutic effects of drugs. Carboxylesterases (CESs), with the main isoforms CES1 and …

Carboxylesterase type 1 (CES1) and CES2 are serine hydrolases located in the liver and
small intestine. CES1 and CES2 actively participate in the metabolism of several …

Ortho‐substituted phenyl‐N‐butyl carbamates (1–11) were synthesized to evaluate the
inhibition mechanisms of porcine pancreatic cholesterol esterase. All carbamate inhibitors …

This review covers current developments in molecular-based studies of the structure and
function of carboxylesterases. To allay the confusion of the classic classification of …

Carboxylesterases are enzymes that hydrolyze a broad suite of endogenous and
exogenous ester-containing compounds to the corresponding alcohol and carboxylic acid …

Background Recently there has been increased interest in pancreatic cholesterol esterase
due to correlation between enzymatic activity in vivo and absorption of dietary cholesterol …

Human carboxylesterase 1A1 (hCES1A) is a promising target for the treatment of
hyperlipidemia and obesity-associated metabolic diseases. To date, the highly specific and …

This review covers current developments in molecular-based studies of the structure and
function of carboxylesterases. To allay the confusion of the classic classification of …

The rhizomes of Alisma orientalis have been used for centuries in China and other Asian
countries as an effective herbal remedy. The phytochemical investigation of A. orientalis and …

The levels of hepatic carboxylesterases, including palmitoyl-CoA hydrolase and decanoyl-D,
l-carnitine hydrolase, were studied in total homogenates and subcellular fractions prepared …