Targeting heme oxygenase-1 by quercetin ameliorates alcohol-induced acute liver injury via inhibiting NLRP3 inflammasome activation

S Liu, L Tian, G Chai, B Wen, B Wang - Food & function, 2018 - pubs.rsc.org
Alcoholic hepatitis (AH) is characterized by inflammation and necrosis of liver tissue caused
by excessive alcohol consumption and it even causes organ failure sometimes, in which …

Quercetin and its metabolites protect hepatocytes against ethanol-induced oxidative stress by activation of Nrf2 and AP-1

YJ Lee, SY Beak, I Choi, JS Sung - Food science and biotechnology, 2018 - Springer
Alcohol-induced liver disease progresses due to increased reactive oxygen species (ROS)
and cellular lipid peroxidation. Quercetin is a flavonoid with strong antioxidant and …

Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways

P Yao, A Nussler, L Liu, L Hao, F Song… - Journal of …, 2007 - Elsevier
BACKGROUND/AIMS: Flavonoids, including quercetin, have been reported to have potent
hepatoprotective effects, which may be associated with HO-1 induction. However, since the …

Nuciferine alleviates acute alcohol-induced liver injury in mice: Roles of suppressing hepatic oxidative stress and inflammation via modulating miR-144/Nrf2/HO-1 …

G Shu, Y Qiu, J Hao, Q Fu, X Deng - Journal of Functional Foods, 2019 - Elsevier
Binge consumption of alcohol results in severe global health problem. This study aimed to
explore the potential efficacy of nuciferine (NCF) in protecting acute alcohol-induced liver …

Quercetin prevents alcohol‑induced liver injury through targeting of PI3K/Akt/nuclear factor‑κB and STAT3 signaling pathway

M Zhu, X Zhou, J Zhao - Experimental and therapeutic …, 2017 - spandidos-publications.com
Quercetin is a type of flavonoid compound, which has potent antioxidant and anti‑
inflammatory activities, capable of treating a variety of diseases including …

Daucosterol Alleviates Alcohol− Induced Hepatic Injury and Inflammation through P38/NF− κB/NLRP3 Inflammasome Pathway

F Zhang, M Wang, Y Zha, J Zhou, J Han, S Zhang - Nutrients, 2023 - mdpi.com
Alcoholic liver disease (ALD) is caused by chronic excessive alcohol consumption, which
leads to inflammation, oxidative stress, lipid accumulation, liver fibrosis/cirrhosis, and even …

Relative protective activities of quercetin, quercetin‐3‐glucoside, and rutin in alcohol‐induced liver injury

S Lee, J Lee, H Lee, J Sung - Journal of food biochemistry, 2019 - Wiley Online Library
Alcoholic liver diseases has been known to be one of the major health risks worldwide. The
purpose of this study was aimed to demonstrate the relative protective effect of quercetin …

Dihydroquercetin (DHQ) ameliorated concanavalin A-induced mouse experimental fulminant hepatitis and enhanced HO-1 expression through MAPK/Nrf2 antioxidant …

M Zhao, J Chen, P Zhu, M Fujino, T Takahara… - International …, 2015 - Elsevier
Autoimmune hepatitis represents a ubiquitous human health problem and has a poor
prognosis. Dihydroquercetin (DHQ), a well-known antioxidant, significantly inhibits fulminant …

Quercetin attenuates NLRP3 inflammasome activation and apoptosis to protect INH-induced liver injury via regulating SIRT1 pathway

Y Zhang, X Qu, H Gao, J Zhai, L Tao, J Sun… - International …, 2020 - Elsevier
Severe hepatotoxicity greatly limits the clinical application of the first-line anti-tuberculosis
drug isoniazid (INH). Quercetin (Que) has multiple pharmacological properties, and is …

Hepatoprotective effect of quercetin against LPS/d-GalN induced acute liver injury in mice by inhibiting the IKK/NF-κB and MAPK signal pathways

Z Peng, X Gong, Y Yang, L Huang, Q Zhang… - International …, 2017 - Elsevier
Quercetin is regarded as a potential hepatoprotective agent in the treatment of acute liver
injury. However, the underlying mechanism of how quercetin to protect against …