Control of autoimmune inflammation using liposomes to deliver positive allosteric modulators of metabotropic glutamate receptors

JM Gammon, AR Adapa… - Journal of Biomedical …, 2017 - Wiley Online Library
Multiple sclerosis (MS) is an autoimmune disease where myelin is incorrectly recognized as
foreign and attacked by the adaptive immune system. Dendritic cells (DCs) direct adaptive …

[HTML][HTML] Controlled delivery of a metabolic modulator promotes regulatory T cells and restrains autoimmunity

JM Gammon, LH Tostanoski, AR Adapa… - Journal of controlled …, 2015 - Elsevier
Autoimmune disorders occur when the immune system abnormally recognizes and attacks
self-molecules. Dendritic cells (DCs) play a powerful role in initiating adaptive immune …

Evaluation of pH-responsive liposomes containing amino acid-based zwitterionic lipids for improving intracellular drug delivery in vitro and in vivo

Y Obata, S Tajima, S Takeoka - Journal of Controlled Release, 2010 - Elsevier
We developed pH-responsive liposomes containing synthetic glutamic acid-based
zwitterionic lipids and evaluated their properties both in vitro and in vivo with the aim of …

RAFTsomes containing epitope-MHC-II complexes mediated CD4+ T cell activation and antigen-specific immune responses

Q Ding, J Chen, X Wei, W Sun, J Mai, Y Yang… - Pharmaceutical …, 2013 - Springer
Purpose To develop a liposome formulation incorporating antigen-presenting cells (APCs)
membrane microdomains with enriched epitope/MHC complexes to evaluate the activities of …

Mechanisms of selective monocyte targeting by liposomes functionalized with a cationic, arginine-rich lipopeptide

R Münter, M Bak, E Christensen, PJ Kempen… - Acta Biomaterialia, 2022 - Elsevier
Stimulation of monocytes with immunomodulating agents can harness the immune system to
treat a long range of diseases, including cancers, infections and autoimmune diseases. To …

Encapsulating an immunosuppressant enhances tolerance induction by Siglec‐engaging tolerogenic liposomes

L Pang, MS Macauley, BM Arlian, CM Nycholat… - …, 2017 - Wiley Online Library
Unwanted antibody responses significantly impact human health, and current options for
treating deleterious antibody responses largely rely on broad immunosuppressants that can …

Incorporation of the TLR4 Agonist Monophosphoryl Lipid A Into the Bilayer of DDA/TDB Liposomes: Physico-Chemical Characterization and Induction of CD8+ T-Cell …

P Nordly, EM Agger, P Andersen, HM Nielsen… - Pharmaceutical …, 2011 - Springer
Purpose The combination of delivery systems like cationic liposomes and
immunopotentiators such as Toll-like receptor (TLR) ligands is a promising approach for …

Accelerated blood clearance and hypersensitivity by PEGylated liposomes containing TLR agonists

C Stavnsbjerg, E Christensen, R Münter… - Journal of Controlled …, 2022 - Elsevier
Systemic administration of toll-like receptor (TLR) agonists have demonstrated impressive
preclinical results as an anti-cancer therapy due to their potent innate immune-stimulatory …

Arginine-based cationic liposomes accelerate T cell activation and differentiation in vitro

T Li, F Tolksdorf, W Sung, H Sato, FJ Eppler… - International Journal of …, 2022 - Elsevier
Cationic liposomes are versatile lipid nanocarriers to improve the pharmacological
properties of drug payloads. Recent advantages include the application of their intrinsic …

Designing lipid nanostructures for local delivery of biologically active macromolecules

M Trif, A Roseanu, JH Brock… - Journal of Liposome …, 2007 - Taylor & Francis
This study focuses on the possible therapeutic utility of liposomes in the local treatment of
inflammatory disorders, specifically rheumatoid arthritis (RA). Our purpose was to design a …