Control of autoimmune inflammation using liposomes to deliver positive allosteric modulators of metabotropic glutamate receptors
Multiple sclerosis (MS) is an autoimmune disease where myelin is incorrectly recognized as
foreign and attacked by the adaptive immune system. Dendritic cells (DCs) direct adaptive …
foreign and attacked by the adaptive immune system. Dendritic cells (DCs) direct adaptive …
[HTML][HTML] Controlled delivery of a metabolic modulator promotes regulatory T cells and restrains autoimmunity
Autoimmune disorders occur when the immune system abnormally recognizes and attacks
self-molecules. Dendritic cells (DCs) play a powerful role in initiating adaptive immune …
self-molecules. Dendritic cells (DCs) play a powerful role in initiating adaptive immune …
Evaluation of pH-responsive liposomes containing amino acid-based zwitterionic lipids for improving intracellular drug delivery in vitro and in vivo
We developed pH-responsive liposomes containing synthetic glutamic acid-based
zwitterionic lipids and evaluated their properties both in vitro and in vivo with the aim of …
zwitterionic lipids and evaluated their properties both in vitro and in vivo with the aim of …
RAFTsomes containing epitope-MHC-II complexes mediated CD4+ T cell activation and antigen-specific immune responses
Purpose To develop a liposome formulation incorporating antigen-presenting cells (APCs)
membrane microdomains with enriched epitope/MHC complexes to evaluate the activities of …
membrane microdomains with enriched epitope/MHC complexes to evaluate the activities of …
Mechanisms of selective monocyte targeting by liposomes functionalized with a cationic, arginine-rich lipopeptide
Stimulation of monocytes with immunomodulating agents can harness the immune system to
treat a long range of diseases, including cancers, infections and autoimmune diseases. To …
treat a long range of diseases, including cancers, infections and autoimmune diseases. To …
Encapsulating an immunosuppressant enhances tolerance induction by Siglec‐engaging tolerogenic liposomes
Unwanted antibody responses significantly impact human health, and current options for
treating deleterious antibody responses largely rely on broad immunosuppressants that can …
treating deleterious antibody responses largely rely on broad immunosuppressants that can …
Incorporation of the TLR4 Agonist Monophosphoryl Lipid A Into the Bilayer of DDA/TDB Liposomes: Physico-Chemical Characterization and Induction of CD8+ T-Cell …
P Nordly, EM Agger, P Andersen, HM Nielsen… - Pharmaceutical …, 2011 - Springer
Purpose The combination of delivery systems like cationic liposomes and
immunopotentiators such as Toll-like receptor (TLR) ligands is a promising approach for …
immunopotentiators such as Toll-like receptor (TLR) ligands is a promising approach for …
Accelerated blood clearance and hypersensitivity by PEGylated liposomes containing TLR agonists
C Stavnsbjerg, E Christensen, R Münter… - Journal of Controlled …, 2022 - Elsevier
Systemic administration of toll-like receptor (TLR) agonists have demonstrated impressive
preclinical results as an anti-cancer therapy due to their potent innate immune-stimulatory …
preclinical results as an anti-cancer therapy due to their potent innate immune-stimulatory …
Arginine-based cationic liposomes accelerate T cell activation and differentiation in vitro
T Li, F Tolksdorf, W Sung, H Sato, FJ Eppler… - International Journal of …, 2022 - Elsevier
Cationic liposomes are versatile lipid nanocarriers to improve the pharmacological
properties of drug payloads. Recent advantages include the application of their intrinsic …
properties of drug payloads. Recent advantages include the application of their intrinsic …
Designing lipid nanostructures for local delivery of biologically active macromolecules
M Trif, A Roseanu, JH Brock… - Journal of Liposome …, 2007 - Taylor & Francis
This study focuses on the possible therapeutic utility of liposomes in the local treatment of
inflammatory disorders, specifically rheumatoid arthritis (RA). Our purpose was to design a …
inflammatory disorders, specifically rheumatoid arthritis (RA). Our purpose was to design a …