In vitro uptake of oligomannose-coated liposomes leads to differentiation of inflammatory monocytes into mature antigen-presenting cells that can activate T cells

Y Matsuoka, Y Kawauchi, Y Kuroda, K Kawauchi… - International …, 2018 - Elsevier
Abstract Oligomannose-coated liposomes (OMLs), containing entrapped antigens, serve as
effective antigen delivery vehicles and as a novel adjuvant to induce antigen-specific …

Drug targeting by long‐circulating liposomal glucocorticosteroids increases therapeutic efficacy in a model of multiple sclerosis

J Schmidt, JM Metselaar, MHM Wauben, KV Toyka… - Brain, 2003 - academic.oup.com
High‐dose glucocorticosteroid hormones are a mainstay in the treatment of relapses in
multiple sclerosis. We searched for a way to deliver ultra high doses of glucocorticosteroids …

Delivery of toll-like receptor agonists by complement C3-targeted liposomes activates immune cells and reduces tumour growth

A Francian, A Widmer, T Olsson, M Ramirez… - Journal of drug …, 2021 - Taylor & Francis
Activation of antigen presenting cells (APCs) is necessary for immune recognition and
elimination of cancer. Our lab has developed a liposome nanoparticle that binds to …

Liposomes with pH responsive 'on and off'switches for targeted and intracellular delivery of antibiotics

CA Omolo, NA Megrab, RS Kalhapure… - Journal of Liposome …, 2021 - Taylor & Francis
Abstract pH responsive drug delivery systems are one of the new strategies to address the
spread of bacterial resistance to currently used antibiotics. The aim of this study was to …

Liposome-based immunotherapy against autoimmune diseases: therapeutic effect on multiple sclerosis

I Pujol-Autonell, MJ Mansilla… - …, 2017 - Taylor & Francis
Aim: Based on the ability of apoptosis to induce immunological tolerance, liposomes were
generated mimicking apoptotic cells, and they arrest autoimmunity in Type 1 diabetes. Our …

[引用][C] Liposomal targeting of glucocorticoids: a novel treatment approach for inflammatory disorders

JM Metselaar - 2003 - Utrecht University

Methyl-Branched Liposomes as a Depot for Sustained Drug Delivery

Y Li, R Shao, CA Ostertag-Hill, M Torre, R Yan… - Nano Letters, 2023 - ACS Publications
Inadequate drug loading and control of payload leakage limit the duration of the effect of
liposomal drug carriers and may cause toxicity. Here, we report a liposome system as a …

Differentially Charged Liposomes Stimulate Dendritic Cells with Varying Effects on Uptake and Processing When Used Alone or in Combination with an Adjuvant

M Maji, S Ghosh, N Didwania, N Ali - ACS omega, 2024 - ACS Publications
Liposomes carrying differential charges have been extensively studied for their role in
stimulating dendritic cells (DCs), major antigen-presenting cells, known to serve as a pivotal …

Mannose-modified celastrol liposomes targeted activated macrophages for rheumatoid arthritis treatment in vitro and in vivo evaluation

J Si, R Guo, L Zhang, W Liu, L Kong, Y Liu, Y Yu… - Journal of Drug Delivery …, 2024 - Elsevier
Rheumatoid arthritis (RA) is an autoimmune illness characterized by symmetrical
polyarthritis as the primary clinical symptom. A substantial number of synovial macrophages …

Monocyte targeting and activation by cationic liposomes formulated with a TLR7 agonist

PT Johansen, D Zucker, L Parhamifar… - Expert Opinion on …, 2015 - Taylor & Francis
Objectives: Monocytes are one of the major phagocytic cells that patrol for invading
pathogens, and upon activation, differentiate into macrophages or antigen-presenting …