Background Few data define the dose-specific relation between alkylating agent exposure
and semen variables in adult survivors of childhood cancer. We undertook this study to test …

Childhood cancer survivors (CCS) have an increased risk of impaired spermatogenesis, but
data regarding the disease‐and treatment‐related risk factors of azoospermia are scarce …

Background The effect of many contemporary chemotherapeutic drugs on pregnancy and
livebirth is not well established. We aimed to establish the effects of these drugs on …

Background Treatment of childhood cancer can result in impaired spermatogenesis.
Intracytoplasmic sperm injection (ICSI), however, can enable men to achieve fatherhood …

Background The reproductive implications of mutagenic treatments given to children with
cancer are not clear. By studying the risk of untoward pregnancy outcomes, we indirectly …

Over the last decade, the number of cancer survivors has increased thanks to progress in
diagnosis and treatment. Cancer treatments are often accompanied by adverse side effects …

Purpose Improved treatment for childhood cancer has led to better survival rates of 83%
today. However, long-term side effects including infertility of pediatric patients receiving …

BACKGROUND Therapy with alkylating agents, such as cyclophosphamide, can be
associated with irreversible gonadal toxicity in male survivors of adult cancer. To the …

Background Previous studies have shown decreased pregnancy rates and early
menopause in female cancer survivors; however, infertility rates and reproductive …

Treatment with chemotherapy, radiotherapy, or surgery that involves reproductive organs
can cause impaired spermatogenesis, testosterone deficiency, and physical sexual …