Background: The efficacy of combination empiric antibiotic therapy for all intensive care unit
(ICU) patients with community-acquired sepsis is a subject of ongoing debate in the era of …

Background: Effective antibiotic therapy is crucial in sepsis management. Studies have
emphasized on antibiotic administration timing more than dosing. We evaluated the …

Quantifying the benefit of early antibiotic treatment is crucial for decision making and can be
assessed only in observational studies. We performed a systematic review of prospective …

Objective To assess the true association between appropriate prescription of antibiotics and
prognosis in patients with sepsis, a key issue in health care and quality improvement …

Severe sepsis and septic shock cause considerable morbidity and mortality. Early
appropriate empiric broad-spectrum antibiotics and advanced resuscitation therapy are the …

Early initiation of effective antibiotic therapy is vitally important for saving the lives of critically
ill patients with sepsis or septic shock. The susceptibility of the infecting pathogen and the …

Purpose Adjusting the antibiotic dose based on an estimation of the glomerular filtration rate
(eGFR) may result in subdosing, which may actually be significantly more problematic for …

Background Outcomes in patients with sepsis are better if initial empirical antimicrobial use
is appropriate. Several studies have shown that adherence to guidelines dictating …

Objectives To determine the attributable mortality and excess length of stay (LOS)
associated with the use of inadequate empirical antimicrobial therapy in patients with sepsis …

Antibiotic resistance can lead to increased morbidity, mortality, length of hospital stay, and
healthcare expenditures. The study is designed to observe the challenges of antibiotic …