ARH van Zanten and KH Polderman increasing incidence of antimicrobial drug resistance
an increased likelihood of inappropriate antimicrobial therapy over the past few years might …

Objective: To evaluate antibiotic prescribing practices in empirical and directed treatment of
severe sepsis and septic shock in Australian and New Zealand intensive care units. Design …

Background Appropriate antibiotics prescribing is key to treatment and to preventing
mortality in patients with sepsis. The aim of this study was to determine the effect of the …

Dosing antibiotics in critically ill patients to achieve therapeutic concentrations is a
significant challenge. The presence of septic shock and prescription of continuous renal …

Optimal dosing of antimicrobial therapy is pivotal to increase the likelihood of survival in
critically ill patients with sepsis. Drug exposure that maximizes bacterial killing, minimizes …

BACKGROUND Early appropriate antibiotic therapy is an important component of the
Surviving Sepsis Guidelines bundles that are associated with decreased in-hospital …

Objectives To determine the rate of de-escalation of the empiric antimicrobial treatment in
ICU patients admitted with sepsis. The characteristics of antimicrobial treatment associated …

Purpose Fast diagnosis and initiation of appropriate antibiotic therapy is pivotal for the
survival of sepsis patients. However, most studies on suspected sepsis patients are …

Background: The appropriate selection of empirical antibiotics based on the pattern of local
antibiotic resistance can reduce the mortality rate and increase the rational use of antibiotics …

Objectives: To describe the impact of initially inappropriate antibiotic therapy on hospital
length of stay in Gram-negative severe sepsis and septic shock. Design: Retrospective …