Introduction There is an ever-increasing range of antibiotic-resistant pathogens that have led
to higher community-acquired infections, and substantial mortality rates in critically ill …

Objectives To assess the effects of empiric antibiotics with different degrees of
appropriateness based on hospital cumulative antibiograms in patients with bacteraemic …

Background: Rapid initiation of antibiotic treatment is considered crucial in patients with
severe infections such as septic shock & bacterial meningitis. The initiation of treatment with …

Background: Maximal dosing of early antimicrobials with high loading and maintenance
doses may optimize pharmacokinetic parameters to achieve and maintain therapeutic …

Objectives Rational use of antibiotics implies appropriate choice of an antibiotic
administered at correct dose, frequency, and duration using the most suitable route of …

Background: A retrospective study was conducted to investigate the validity and the
effectiveness of early empiric antibiotic and de-escalation therapy for the treatment of severe …

Aminoglycosides are among the most widely used antibiotics in intensive care units (ICU),
despite demonstrated absence of survival benefits when added to b-lactam therapy and …

The outcome for critically ill patients is burdened by a double mortality rate and a longer
hospital stay in the case of sepsis or septic shock. The adequate use of antibiotics may …

Objectives To perform an audit of empirical antibiotic therapy (EAT) of sepsis at the
emergency department and to analyse the impact of an antimicrobial stewardship (AMS) …

Background Acute kidney injury (AKI) is a common complication of sepsis, contributing to an
increased mortality rate. However, some studies have demonstrated that renal function …