Objectives Antibiotic treatment is vital in patients with severe sepsis/septic shock. The
objectives were to assess the degree of concordance between antibiotic prescribed in …

Background The optimal dosing of antibiotics in critically ill patients receiving renal
replacement therapy (RRT) remains unclear. In this study, we describe the variability in RRT …

Introduction: Severe infections in critically ill patients carry a high morbidity and mortality
rate. Given the impact of early and broad-spectrum empirical therapy in several studies and …

Objective The purpose of this study was to analyze the improvement effect of clinical
pharmacist intervention on renal function impairment in patients with antimicrobial-induced …

Objective: To assess appropriate antimicrobial therapy as an outcome determinant in severe
sepsis and septic shock using the number needed to treat. Design: Single-center cohort …

Objective: To study the presence of bacterial disease and antibiotic use in patients in the
emergency department (ED) included in the local sepsis protocol. Methods: An …

Abstract Purpose of Review Early antibiotic administration is the cornerstone of sepsis
treatment guidelines and quality measures. We summarize recent key literature on sepsis …

Background As the susceptibility pattern of different pathogens varies among different
settings, the evaluation of appropriate clinical diagnosis and timely initiation of the empirical …

HOW EARLY DO ANTIBIOTICS HAVE TO BE TO IMPACT MORTALITY IN SEVERE SEPSIS? A
PROSPECTIVE, OBSERVATIONAL STUDY FROM AN EMERGENCY D Page 1 J Ayub Med …

Sepsis affects approximately 750,000 individuals in the United States each year, accounting
for 2.1% to 4.3% of hospitalizations, and 11% of all admissions to the ICU. 1 From 1979 to …