Prognostic values of EPDR1 hypermethylation and its inhibitory function on tumor invasion in colorectal cancer

CH Chu, SC Chang, HH Wang, SH Yang, KC Lai… - Cancers, 2018 - mdpi.com
Aberrant DNA methylation is a potential mechanism underlying the development of
colorectal cancer (CRC). Thus, identification of prognostic DNA methylation markers and …

DNA methylation changes in genes frequently mutated in sporadic colorectal cancer and in the DNA repair and Wnt/β-catenin signaling pathway genes

SA Farkas, V Vymetalkova, L Vodickova, P Vodicka… - …, 2014 - Taylor & Francis
Aim: The onset and progression of colorectal cancer (CRC) involves a cascade of genetic
and/or epigenetic events. The aim of the present study was to address the DNA methylation …

Aberrantly methylated-differentially expressed genes and pathways in colorectal cancer

J Liu, H Li, L Sun, Z Wang, C Xing, Y Yuan - Cancer Cell International, 2017 - Springer
Background Methylation plays an important role in the etiology and pathogenesis of
colorectal cancer (CRC). This study aimed to identify aberrantly methylated-differentially …

Hypermethylation of PDX1, EN2, and MSX1 predicts the prognosis of colorectal cancer

Y Lee, SH Dho, J Lee, JH Hwang, M Kim… - … & molecular medicine, 2022 - nature.com
Despite numerous observations regarding the relationship between DNA methylation
changes and cancer progression, only a few genes have been verified as diagnostic …

Hypermethylation of EDNRB promoter contributes to the risk of colorectal cancer

C Chen, L Wang, Q Liao, Y Huang, H Ye, F Chen… - Diagnostic …, 2013 - Springer
Objective Colorectal cancer (CRC) is one of the most common digestive malignancies in the
world. EDNRB is a new candidate tumor suppressor gene which is often down-regulated or …

Genome-wide methylation profiling identified novel differentially hypermethylated biomarker MPPED2 in colorectal cancer

S Gu, S Lin, D Ye, S Qian, D Jiang, X Zhang, Q Li… - Clinical …, 2019 - Springer
Background Epigenetic alternation is a common contributing factor to neoplastic
transformation. Although previous studies have reported a cluster of aberrant promoter …

EPDR1 up-regulation in human colorectal cancer is related to staging and favours cell proliferation and invasiveness

F Gimeno-Valiente, AL Riffo-Campos, G Ayala… - Scientific Reports, 2020 - nature.com
The finding of novel molecular markers for prediction or prognosis of invasiveness in
colorectal cancer (CRC) constitutes an appealing challenge. Here we show the up …

Genome-wide screening for understanding the role of DNA methylation in colorectal cancer

F Sipos, G Mũzes, AV Patai, I Fũri, B Péterfia… - …, 2013 - Taylor & Francis
DNA methylation analysis methods have undergone an impressive revolution over the past
15 years. Regarding colorectal cancer (CRC), the localization and distribution of several …

Comparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues

F Simmer, AB Brinkman, Y Assenov, F Matarese… - Epigenetics, 2012 - Taylor & Francis
Aberrant DNA methylation often occurs in colorectal cancer (CRC). In our study we applied a
genome-wide DNA methylation analysis approach, MethylCap-seq, to map the differentially …

Genome-wide analysis of cell-Free DNA methylation profiling with MeDIP-seq identified potential biomarkers for colorectal cancer

X Zhang, T Li, Q Niu, C Qin, M Zhang, G Wu… - World Journal of …, 2022 - Springer
Background Colorectal cancer is the most common malignancy and the third leading cause
of cancer-related death worldwide. This study aimed to identify potential diagnostic …