A semi-automated method for generating hyperpolarized helium-3 (3 He) measurements of
individual slice (2D) or whole lung (3D) gas distribution was developed. 3 He MRI functional …

The pulse sequences for hyperpolarized 3He lung MRI that have made the most clinical
impact to date are 1) those that supply regional apparent diffusion coefficient (ADC) …

Rationale: Cystic Fibrosis (CF) lung disease progresses through a vicious cycle of recurrent
infection and inflammation, resulting in permanent airway remodeling (eg, bronchiectasis) …

The study of lung emphysema dates back to the beginning of the 17th century. Nevertheless,
a number of important questions remain unanswered because a quantitative localized …

Hyperpolarized 3 He diffusion MRI is increasingly used to non‐invasively quantify local
alveolar structure changes, such as those from Chronic Obstructive Pulmonary Disease …

Clinical magnetic resonance imaging of the lung is technologically challenging, yet over the
past two decades hyperpolarized noble gas (3He and 129Xe) imaging has demonstrated …

Both the development of accurate models of lung function and their quantitative validation
can be significantly enhanced by the use of functional imaging techniques. The advent of …

Purpose The goal of this work was to investigate lung morphological changes associated
with chronic obstructive pulmonary disease (COPD) using hyperpolarized 129Xe diffusion …

Chronic obstructive pulmonary disease (COPD) is the 4 th leading cause of death worldwide
and accounts for the highest rate of hospital admissions in Canada. The need for sensitive …

Purpose To obtain whole lung morphometry measurements from 129Xe in a single breath‐
hold with 3D multiple b‐value 129Xe diffusion‐weighted MRI (DW‐MRI) with an empirically …