Hyperpolarized 3He diffusion experiments have been shown to be sensitive to changes in
acinar structure due to emphysematous lung disease. Extracting quantitative information …

The main objective of this project was to develop and implement techniques for high-
resolution quantitative imaging of ventilation in lungs using hyperpolarized gas magnetic …

Recently, the apparent diffusion coefficient (ADC) of 3He has been measured in animal
models [1] and in humans [2, 3, 4]. Mugler et al.[2] measured the ADC in healthy volunteers …

INTRODUCTION: The clinical lung evaluation methods currently in use fail to provide
regional information to detect the small changes in patient's response to therapeutic …

Although 3He MRI permits compelling visualization of the pulmonary air spaces, quantitation
of absolute ventilation is difficult due to confounds such as field inhomogeneity and relative …

While high quality MR Images of lungs are difficult to obtain with conventional proton MRI
due to the organ's low tissue density, the advent of techniques in noble gas polarization …

RATIONALE: Hyperpolarized Helium− 3 (Hyp 3He) MRI has been used for qualitative
detection of ventilation defects in asthma. Previous quantitative methods have relied on …

In imaging of human lungs with hyperpolarised noble gases, measurements of apparent
diffusion coefficient (ADC) and relaxation time provide valuable information for the …

Purpose Diffusion and lung morphometry imaging using hyperpolarized gases are
promising tools to quantify pulmonary microstructure noninvasively in humans and in animal …

The validity of current theoretical models of hyperpolarized gas MR diffusion used to quantify
lung microstructure is limited by their use of simplified geometries. This work describes de …