Lung diseases affect the conducting airways, the gas exchange parenchyma, or both. As a
result, they have a high impact on patients' morbidity, and quality of life. Chronic obstructive …

Background: Single breath washout (SBW) can be used to measure Phase III slope (SIII) as
a surrogate of ventilation heterogeneity. Nevertheless the impact of factors contributing to …

Pulmonary function in adults is known to decline with age. Using non-invasive diffusion MRI-
based in vivo helium-3 lung morphometry, we studied 38 healthy subjects (ages 18-70) to …

Smoking-related lung diseases including chronic obstructive pulmonary disease (COPD)
and lung cancer are projected to have claimed the lives of more than 30,000 Canadians in …

Abstract 3 He magnetic resonance imaging (MRI) is capable of producing new and regional
information on normal and abnormal lung ventilation. The basis of 3 He MRI involves …

Adapting established PRM methodology, we developed a gas MR-based technique suitable
for voxel-wise analysis of multiple simultaneous parameters of HP gas imaging in order to …

Compressed sensing has been applied to hyperpolarized gas MRI to accelerate acquisition
and allow for increased data or resolution. To better understand the effect of compressed …

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the
world. Identifying clinically relevant COPD phenotypes has the potential to reduce the global …

Introduction: Alveolar ventilation is distributed non-uniformly throughout the lungs. Caused
by a combination lung mechanics, asymmetrical structure and compliance, and gravity, this …