RESULTS Each subdivided class, as well as the combined group, was analyzed. The
number of patients who improved objectively (obj.+) or did not (obj.-) and/or subjectively …

Glucocorticoids (GC) are essential steroid hormones for human life. They regulate a series
of important processes by binding with three glucocorticoid receptors (GR) and activating …

Two hundred and four patients with progressive locally advanced or metastatic breast
cancer not controllable by local therapy alone, and who had had no prior systemic therapy …

Opinion statement Corticosteroids have been used in the management of prostate cancer for
over 30 years. Although daily oral corticosteroids have frequently used in conjunction with …

AIM: To determine how glucocorticoids (GCs) may affect the growth and chemosensitivity of
common carcinoma cells. METHODS: The effect of dexamethasone (DEX) on growth and …

The glucocorticoid dexamethasone is frequently used as a co-treatment in cytotoxic cancer
therapy, eg to prevent nausea, to protect normal tissue or for other reasons. While the potent …

Background: Use of immunosuppressive drugs post organ transplantation, and prolonged
use of glucorticoids for other conditions have been associated with subsequent risk of …

Purpose A synthetic glucocorticoid, dexamethasone, was recently shown to inhibit bladder
cancer cell invasion and metastasis through the glucocorticoid receptor (GR) pathway but …

Background Glucocorticoid receptor (GR) activity plays a role in many aspects of human
physiology and may play a crucial role in chemotherapy resistance in a wide variety of solid …

PURPOSE A randomized study comparing low-dose aminoglutethimide (AG) with and
without hydrocortisone (HC) was performed to investigate whether corticosteroid …