▪ Abstract New insights into mammalian zinc metabolism have been acquired through the
identification and characterization of zinc transporters. These proteins all have …

Intracellular homeostasis for zinc is achieved through the coordinate regulation of specific
transporters engaged in zinc influx, efflux, and intracellular compartmentalization. We have …

Zinc, which is essential for many cellular processes, is controlled by zinc transporters and
through buffering by metallothioneins and glutathione. Although zinc is increasingly …

The SLC39A family of zinc transporters can be divided into four subfamilies (I, II, LIV-1, and
gufA) in vertebrates, but studies of their functions have been restricted exclusively to …

Zinc transporters (ZnT) form an important class of zinc efflux proteins in mammals. Nine ZnT
transporters, designated ZnT1–ZnT8 and ZnT10, have been identified to date. Recent …

Zinc (Zn) is an essential trace mineral that regulates the expression and activation of
biological molecules such as transcription factors, enzymes, adapters, channels, and growth …

Zinc (Zn) is a vital element. It plays indispensable roles in multifarious cellular processes,
affecting the expression and activity of a variety of molecules, including transcription factors …

Zinc is required for the regulation of proliferation, metabolism, and cell signaling. It is an
intracellular second messenger, and the cellular level of ionic, mobile zinc is strictly …

Fourteen members of the Slc39a superfamily of metal ion uptake transporters have been
identified in mice and humans, but the physiological functions of most remain obscure …

Zinc is essential to a wide range of cellular processes; therefore, it is important to elucidate
the molecular mechanisms of zinc homeostasis. To date, no zinc transporters expressed at …