Zinc is an essential mineral, and infants are particularly vulnerable to zinc deficiency as they
require large amounts of zinc for their normal growth and development. We have recently …

The group IIb metal zinc (Zn) is an essential dietary component that can be found in protein
rich foods such as meat, seafood and legumes. Thousands of genes encoding Zn binding …

ZnT7, a novel member of the zinc transporter (ZnT) family, was identified by searching the
expressed sequence tag (EST) databases with the amino acid sequence of ZnT1. Like the …

Expression of five zinc transporters (ZnT1, 4, 5, 6, and 7) of the Slc30 family in the mouse
gastrointestinal tract was studied by immunohistochemical analysis. Results demonstrated …

We have identified the Dri 27 cDNA on the basis of its upregulated expression during rat
intestinal development. It encodes a hydrophobic protein of 430 amino acids that shares …

Around 3000 proteins are thought to bind zinc in vivo, which corresponds to~ 10% of the
human proteome. Zinc plays a pivotal role as a structural, catalytic, and signaling component …

Cadmium is a dangerous metal distributed widely in the environment. Members of our
laboratory recently identified the ZIP8 transporter protein, encoded by the mouse Slc39a8 …

Dietary zinc deficiency in mice is accompanied by enhanced expression of the zinc uptake
transporter Slc39a4 (Zip4) and repressed expression of Slc39a5 (Zip5) in tissues which …

Zinc is essential but potentially toxic, so intracellular zinc levels are tightly controlled. A key
strategy used by many organisms to buffer cytosolic zinc is to store it within vesicles and …

Vesicular zinc transporters (ZnTs) play a critical role in regulating Zn 2+ homeostasis in
various cellular compartments and are linked to major diseases ranging from Alzheimer …