As an essential nutrient, manganese is required for the regulation of numerous cellular
processes, including cell growth, neuronal health, immune cell function, and antioxidant …

The last ten years have witnessed major advances in our understanding of zinc transporters
and their regulation in eukaryotic organisms. Two families of transporters, the ZIP (Zrt-, I rt …

It has been suggested that ZIP7 (Ke4, Slc39a7) belongs to the ZIP family of zinc transporters.
Transient expression of the V5-tagged human ZIP7 fusion protein in CHO cells led to …

We describe ZnT6, a new member of the CDF (cation diffusion facilitator) family of heavy
metal transporters. The humanZNT6 gene was mapped at 2p21–22, while the mouseZnt6 …

Abstract ZnT-1 is a Cation Diffusion Facilitator (CDF) family protein, and is present
throughout the phylogenetic tree from bacteria to humans. Since its original cloning in 1995 …

The mouse and human genomes contain 14 highly conserved SLC39 genes. Viewed from
an evolutionary perspective, SLC39A14 and SLC39A8 are the most closely related, each …

Solute carrier family 39, member 14 (SLC39A14) is a transmembrane transporter that can
mediate the cellular uptake of zinc, iron, and manganese (Mn). Studies of Slc39a14 …

The SLC39A family of metal transporters was identified through homologies with the Zrt-and
Irt-like (ZIP) proteins from yeast and plants. Of all the ZIP transporters, ZIP14 is arguably the …

Zinc is the second most abundant transition metal in the body. Despite the fact that hundreds
of biomolecules require zinc for proper function and/or structure, the mechanism of zinc …

Zinc is an essential micronutrient affecting many aspects of human health. Cellular Zn 2+
homeostasis is critical for cell function and survival. Zn 2+, acting as a first or second …