How cellular Zn2+ signaling drives physiological functions
N Levaot, M Hershfinkel - Cell Calcium, 2018 - Elsevier
Zinc is an essential micronutrient affecting many aspects of human health. Cellular Zn 2+
homeostasis is critical for cell function and survival. Zn 2+, acting as a first or second …
homeostasis is critical for cell function and survival. Zn 2+, acting as a first or second …
[HTML][HTML] Mammalian zinc transporters
RJ McMahon, RJ Cousins - The Journal of nutrition, 1998 - Elsevier
Genes that are involved in mammalian zinc transport recently have been cloned. These all
predict proteins with multiple membrane spanning regions, and most have a histidine-rich …
predict proteins with multiple membrane spanning regions, and most have a histidine-rich …
The human ZIP4 transporter has two distinct binding affinities and mediates transport of multiple transition metals
S Antala, RE Dempski - Biochemistry, 2012 - ACS Publications
Zinc is the second most abundant transition metal in the body. Despite the fact that hundreds
of biomolecules require zinc for proper function and/or structure, the mechanism of zinc …
of biomolecules require zinc for proper function and/or structure, the mechanism of zinc …
Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion
LD Pound, SA Sarkar, RKP Benninger… - Biochemical …, 2009 - portlandpress.com
The Slc30a8 gene encodes the islet-specific zinc transporter ZnT-8, which provides zinc for
insulin-hexamer formation. Polymorphic variants in amino acid residue 325 of human ZnT-8 …
insulin-hexamer formation. Polymorphic variants in amino acid residue 325 of human ZnT-8 …
SLC39A10 promotes malignant phenotypes of gastric cancer cells by activating the CK2-mediated MAPK/ERK and PI3K/AKT pathways
X Ren, C Feng, Y Wang, P Chen, S Wang… - … & Molecular Medicine, 2023 - nature.com
Solute carrier family 39 member 10 (SLC39A10) belongs to a subfamily of zinc transporters
and plays a key role in B-cell development. Previous studies have reported that its …
and plays a key role in B-cell development. Previous studies have reported that its …
The role of zinc transporters in cadmium and manganese transport in mammalian cells
S Himeno, T Yanagiya, H Fujishiro - Biochimie, 2009 - Elsevier
To understand the mechanism of cadmium accumulation, it is important to know the precise
mechanisms of transport systems for other metals. Recently, utilization of genomics and …
mechanisms of transport systems for other metals. Recently, utilization of genomics and …
The Zinc Transporter, Slc39a7 (Zip7) Is Implicated in Glycaemic Control in Skeletal Muscle Cells
SA Myers, A Nield, GS Chew, MA Myers - PLoS One, 2013 - journals.plos.org
Dysfunctional zinc signaling is implicated in disease processes including cardiovascular
disease, Alzheimer's disease and diabetes. Of the twenty-four mammalian zinc transporters …
disease, Alzheimer's disease and diabetes. Of the twenty-four mammalian zinc transporters …
[HTML][HTML] Manganese transport in mammals by zinc transporter family proteins, ZNT and ZIP
H Fujishiro, T Kambe - Journal of Pharmacological Sciences, 2022 - Elsevier
Manganese (Mn) is an essential trace element required for various biological processes.
However, excess Mn causes serious side effects in humans, including parkinsonism. Thus …
However, excess Mn causes serious side effects in humans, including parkinsonism. Thus …
Zinc transport complexes contribute to the homeostatic maintenance of secretory pathway function in vertebrate cells
K Ishihara, T Yamazaki, Y Ishida, T Suzuki… - Journal of Biological …, 2006 - ASBMB
Zinc transporters play important roles in a wide range of biochemical processes. Here we
report an important function of ZnT5/ZnT6 hetero-oligomeric complexes in the secretory …
report an important function of ZnT5/ZnT6 hetero-oligomeric complexes in the secretory …
Responsive transporter genes within the murine intestinal-pancreatic axis form a basis of zinc homeostasis
JP Liuzzi, JA Bobo, LA Lichten… - Proceedings of the …, 2004 - National Acad Sciences
Zn homeostasis in animals is a consequence of avid uptake and retention, except during
conditions of limited dietary availability, and/or factors such as parasites, which compete for …
conditions of limited dietary availability, and/or factors such as parasites, which compete for …