Zinc is an essential micronutrient affecting many aspects of human health. Cellular Zn 2+
homeostasis is critical for cell function and survival. Zn 2+, acting as a first or second …

Genes that are involved in mammalian zinc transport recently have been cloned. These all
predict proteins with multiple membrane spanning regions, and most have a histidine-rich …

Zinc is the second most abundant transition metal in the body. Despite the fact that hundreds
of biomolecules require zinc for proper function and/or structure, the mechanism of zinc …

The Slc30a8 gene encodes the islet-specific zinc transporter ZnT-8, which provides zinc for
insulin-hexamer formation. Polymorphic variants in amino acid residue 325 of human ZnT-8 …

Solute carrier family 39 member 10 (SLC39A10) belongs to a subfamily of zinc transporters
and plays a key role in B-cell development. Previous studies have reported that its …

To understand the mechanism of cadmium accumulation, it is important to know the precise
mechanisms of transport systems for other metals. Recently, utilization of genomics and …

Dysfunctional zinc signaling is implicated in disease processes including cardiovascular
disease, Alzheimer's disease and diabetes. Of the twenty-four mammalian zinc transporters …

Manganese (Mn) is an essential trace element required for various biological processes.
However, excess Mn causes serious side effects in humans, including parkinsonism. Thus …

Zinc transporters play important roles in a wide range of biochemical processes. Here we
report an important function of ZnT5/ZnT6 hetero-oligomeric complexes in the secretory …

Zn homeostasis in animals is a consequence of avid uptake and retention, except during
conditions of limited dietary availability, and/or factors such as parasites, which compete for …