Role of infection and antimicrobial therapy in acute exacerbations of chronic obstructive pulmonary disease

FJ Martinez, ML K Han, K Flaherty… - Expert review of anti …, 2006 - Taylor & Francis
Over the past several years, the significance of acute exacerbations of chronic obstructive
pulmonary disease (AECOPD) in patients with chronic airflow obstruction has become …

Pathogenesis of inflammation and repair in advanced COPD

WD Cornwell, V Kim, C Song… - Seminars in respiratory …, 2010 - thieme-connect.com
Chronic obstructive pulmonary disease is characterized by an abnormal persistent
inflammatory response to noxious environmental stimuli, most commonly cigarette smoke …

Diagnosis of pathogens in exacerbations of chronic obstructive pulmonary disease

A Sykes, P Mallia, SL Johnston - Proceedings of the American …, 2007 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is increasing in prevalence. Acute
exacerbations of COPD are the major cause worldwide of morbidity, mortality, and health …

Dynamics of pro-inflammatory and anti-inflammatory cytokine release during acute inflammation in chronic obstructive pulmonary disease: an ex vivo study

TL Hackett, R Holloway, ST Holgate, JA Warner - Respiratory research, 2008 - Springer
Abstract Background Exacerbations of Chronic obstructive pulmonary disease (COPD) are
an important cause of the morbidity and mortality associated with the disease. Strategies to …

Treatment of patients with COPD and recurrent exacerbations: the role of infection and inflammation

S Santos, A Marin, J Serra-Batlles… - … journal of chronic …, 2016 - Taylor & Francis
Exacerbations of COPD represent an important medical and health care problem. Certain
susceptible patients suffer recurrent exacerbations and as a consequence have a poorer …

Building toolkits for COPD exacerbations: lessons from the past and present

E Sapey, M Bafadhel, CE Bolton, T Wilkinson, JR Hurst… - Thorax, 2019 - thorax.bmj.com
In the nineteenth century, it was recognised that acute attacks of chronic bronchitis were
harmful. 140 years later, it is clearer than ever that exacerbations of chronic obstructive …

Bacterial–viral load and the immune response in stable and exacerbated COPD: significance and therapeutic prospects

SE D'Anna, B Balbi, F Cappello, M Carone… - … Journal of Chronic …, 2016 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow
limitation and an abnormal inflammatory response of the lung. Bacteria and viruses are a …

Chronic obstructive pulmonary disease: histopathology, inflammation and potential therapies

NA Molfino, PK Jeffery - Pulmonary Pharmacology & Therapeutics, 2007 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a major worldwide health burden with
increasing morbidity, mortality and health care cost. It is a slowly progressive chronic …

COPD exacerbations: impact and prevention

JA Wedzicha, AJ Mackay, R Singh - Breathe, 2013 - Eur Respiratory Soc
Educational aims To describe the impact of COPD exacerbations and the importance of the
frequent exacerbator phenotype. To describe the spectrum of pharmacological and non …

Infection in the pathogenesis and course of chronic obstructive pulmonary disease

S Sethi, TF Murphy - New England Journal of Medicine, 2008 - Mass Medical Soc
New molecular, cellular, and immunologic techniques used to study host–pathogen
interactions have led to a reexamination of the role of infection in chronic obstructive …