[HTML][HTML] Association of CYP3A polymorphisms with the pharmacokinetics of cyclosporine A in early post-renal transplant recipients in China
X Meng, C Guo, G Feng, Y Zhao, B Zhou… - Acta Pharmacologica …, 2012 - nature.com
Aim: To evaluate retrospectively the association of cytochrome P450 3A (CYP3A) and ATP-
binding cassette sub-family B member 1 (ABCB1) gene polymorphisms with the …
binding cassette sub-family B member 1 (ABCB1) gene polymorphisms with the …
[HTML][HTML] Effect of CYP3A4, CYP3A5, MDR1 and POR Genetic Polymorphisms in Immunosuppressive Treatment in Chilean Kidney Transplanted Patients
S Contreras-Castillo, A Plaza, J Stojanova… - Frontiers in …, 2021 - frontiersin.org
Cyclosporine (CsA) and tacrolimus (TAC) are immunosuppressant drugs characterized by a
narrow therapeutic range and high pharmacokinetic variability. The effect of polymorphisms …
narrow therapeutic range and high pharmacokinetic variability. The effect of polymorphisms …
Multi‐drug resistance gene‐1 (MDR‐1) haplotypes and the CYP3A5*1 genotype have no influence on ciclosporin dose requirements as assessed by C0 or C2 …
S Fredericks, AM Jorga, IAM MacPhee… - Clinical …, 2007 - Wiley Online Library
The intestinal efflux pump P‐glycoprotein (P‐gp), the product of the multi‐drug resistance‐1
(MDR‐1) gene, significantly influences the pharmacokinetics of several drugs. Ciclosporin is …
(MDR‐1) gene, significantly influences the pharmacokinetics of several drugs. Ciclosporin is …
The effect of CYP3A5 polymorphism on dose-adjusted cyclosporine concentration in renal transplant recipients: a meta-analysis
HJ Zhu, SH Yuan, Y Fang, XZ Sun, H Kong… - The pharmacogenomics …, 2011 - nature.com
Cyclosporine (CsA) is a substrate of cytochrome P450 (CYP) 3A5 and has a narrow
therapeutic range with large inter-individual variability. CYP3A5* 3 polymorphism is reported …
therapeutic range with large inter-individual variability. CYP3A5* 3 polymorphism is reported …
Influence of CYP3A and MDR1 genetic polymorphisms on the pharmacokinetics of ciclosporin A
YF XU - Journal of International Pharmaceutical Research, 2015 - pesquisa.bvsalud.org
Ciclosporin A (CsA). an immunosuppressive macrolide antibiotics, is widely applied to
prevent rejections after organ transplants. CsA is mainly transported by P-glycoprotein (P …
prevent rejections after organ transplants. CsA is mainly transported by P-glycoprotein (P …
Impact of CYP3A4 and MDR1 gene (G2677T) polymorphisms on dose requirement of the cyclosporine in renal transplant Egyptian recipients
Advances in immunosuppressive therapy allowed renal transplantation to become the
treatment of choice for suitable candidates with (end stage renal disease) ESRD. The post …
treatment of choice for suitable candidates with (end stage renal disease) ESRD. The post …
Influence of the MDR1 haplotype and CYP3A5 genotypes on cyclosporine blood level in Chinese renal transplant recipients
B Chen, W Zhang, J Fang, Z Jin, J Li, Z Yu, W Cai - Xenobiotica, 2009 - Taylor & Francis
The purpose of the study was to elucidate the influence of multidrug resistance gene
(MDR1) haplotype and CYP3A5 genotype on cyclosporine (CsA) blood level in Chinese …
(MDR1) haplotype and CYP3A5 genotype on cyclosporine (CsA) blood level in Chinese …
Effect of genetic polymorphisms of CYP3A5 and MDR1 on cyclosporine concentration during the early stage after renal transplantation in Chinese patients co-treated …
Y Wang, C Wang, J Li, X Wang, G Zhu, X Chen… - European journal of …, 2009 - Springer
Objective The aim of this study was to assess the influence of the cytochrome (CYP450) 3A5
and multidrug resistance (MDR1) gene polymorphisms on cyclosporine A (CsA) trough …
and multidrug resistance (MDR1) gene polymorphisms on cyclosporine A (CsA) trough …
Population pharmacokinetics of cyclosporine in kidney and heart transplant recipients and the influence of ethnicity and genetic polymorphisms in the MDR‐1 …
DA Hesselink, T van Gelder… - Clinical …, 2004 - Wiley Online Library
Objective Our objective was to determine the relationship between single nucleotide
polymorphisms (SNPs) in the multidrug resistance 1 (MDR‐1) gene and the cytochrome …
polymorphisms (SNPs) in the multidrug resistance 1 (MDR‐1) gene and the cytochrome …
Polymorphisms of multidrug resistance gene (MDR1) and cyclosporine absorption in de novo renal transplant patients
CJ Foote, W Greer, B Kiberd, A Fraser, J Lawen… - …, 2007 - journals.lww.com
Background. Several single nucleotide polymorphisms (SNPs) in the multidrug resistance
(MDR1) gene may play a role in the interindividual variation of cyclosporine A (CsA) …
(MDR1) gene may play a role in the interindividual variation of cyclosporine A (CsA) …