Aim: To investigate whether the CYP3A5* 3 polymorphism would affect cyclosporine A (CsA)
metabolism in Chinese renal transplant patients. Methods: The CYP3A5* 3 genotype was …

Background: Cyclosporine is used as an immunosuppressive agent in kidney
transplantation. It has a narrow therapeutic window. Cyclosporine is predominantly …

Objective: To evaluate the correlation of inter-individual variation of cyclosporine dosage
and blood concentration and CYP3A4 and CYP3A5 polymorphism in renal transplant …

Immunosuppressive drugs, such as tacrolimus (FK506) and cyclosporine (CsA), play an
essential role in graft survival, preventing rejection. Large interindividual differences in drug …

Cyclosporine A (CsA), mainly metabolized by cytochrome P450 (CYP) 3A, presents a wide
interindividual variability in its kinetics. CYP3A4 and CYP3A5 are members of the CYP3A …

Aim To evaluate retrospectively the effect of genetic polymorphisms in CYP3A4 and
CYP3A5 on cyclosporine pharmacokinetics during the early period in renal transplant …

Background. Cyclosporine A (CsA) is characterized by high interindividual variations in oral
bioavailability and a narrow therapeutic index. CsA is a substrate for P-glycoprotein, a …

En el Hospital Carlos Van Buren de Valparaíso se realizó un estudio para identificar los
factores que influyen en las concentraciones plasmáticas de ciclosporina en trasplantados …

OBJECTlVE To investigate the association between CYP3A5 genotypes and the early
efficacy of tacrolimus (Tac) and cyclosporin A (CsA) in renal transplantation recipients, and …

Objective Cyclosporine A (CsA) is a substrate of cytochrome P450 3A4 (CYP3A4). Recently,
a newly discovered intron 6 single-nucleotide polymorphism in CYP3A4 (rs35599367 C> T) …