Research current situation and progress on pharmacogenomics and personalized medicine of cyclosporine A
Y DAI, J ZHANG, M LIN… - Chinese Journal of …, 2014 - manu41.magtech.com.cn
Cyclosporine (CsA), as a novel potent immunosuppressant, is widely used in organ
transplantation in recent years. Due to its narrow therapeutic index and individual difference …
transplantation in recent years. Due to its narrow therapeutic index and individual difference …
MDR1 Haplotypes Do Not Affect the Steady‐State Pharmacokinetics of Cyclosporine in Renal Transplant Patients
I Mai, E Störmer, M Goldammer, A Johne… - The Journal of …, 2003 - Wiley Online Library
This retrospective study investigated the impact of MDR1 haplotypes derived from the single‐
nucleotide polymorphisms (SNPs) 2677G> T (exon 21) and 3435C> T (exon 26) on the …
nucleotide polymorphisms (SNPs) 2677G> T (exon 21) and 3435C> T (exon 26) on the …
ABCB1 genotype of the donor but not of the recipient is a major risk factor for cyclosporine-related nephrotoxicity after renal transplantation
IA Hauser, E Schaeffeler, S Gauer… - Journal of the …, 2005 - journals.lww.com
Cyclosporine (CsA) nephrotoxicity is a severe complication in organ transplantation
because it leads to impaired renal function and chronic allograft nephropathy, which is a …
because it leads to impaired renal function and chronic allograft nephropathy, which is a …
Effect of CYP3A5 polymorphisms on pharmacokinetic interaction between cyclosporine and diltiazem in Thai renal allograft recipients
P Wannapraphan - 2011 - cuir.car.chula.ac.th
Cyclosporine (CsA) is frequently coadministration with Diltiazem (DTZ) because the latter
has possible beneficial effect on the economic impact associated with reduction of the daily …
has possible beneficial effect on the economic impact associated with reduction of the daily …
Multidrug-resistance 1 gene single-nucleotide polymorphisms do not influence long-term graft survival after kidney transplantation
A Saracino, N Muscaridola, RA Cifarelli… - Transplantation …, 2014 - Elsevier
Background The single-nucleotide polymorphisms (SNPs) of the Multidrug resistance 1
(MDR1) gene have been associated with changes in the pharmacokinetics of cyclosporine …
(MDR1) gene have been associated with changes in the pharmacokinetics of cyclosporine …
POLYMORPHISMS OF MDR1 AND CYCLOSPORINE ABSORPTION IN DE NOVO RENAL TRANSPLANT PATIENTS
CJ Foote, W Greer, B Kiberd, A Fraser, J Lawen… - …, 2004 - journals.lww.com
Aims: The aim of this study was to determne whether polymorphisms of MDR1 (ABC1) help
explain the significant interindividual variability in Cyclosporine (CsA) absorption and …
explain the significant interindividual variability in Cyclosporine (CsA) absorption and …
Amlodipine, but not MDR1 polymorphisms, alters the pharmacokinetics of cyclosporine A in Japanese kidney transplant recipients1
T Kuzuya, T Kobayashi, N Moriyama, T Nagasaka… - …, 2003 - journals.lww.com
Background. Cyclosporine A (CsA) is a critical immunosuppressive drug with a narrow
therapeutic range and wide interindividual variation in its pharmacokinetics. Many factors …
therapeutic range and wide interindividual variation in its pharmacokinetics. Many factors …
CYP3A5 genotype is associated with longer patient survival after kidney transplantation and long-term treatment with cyclosporine
R Kreutz, J Bolbrinker… - The …, 2008 - nature.com
Abstract The CYP3A5* 1 allele has been linked to high expression of CYP3A5 and
metabolism of cyclosporine. We evaluated the role of CYP3A5* 1 for long-term survival in …
metabolism of cyclosporine. We evaluated the role of CYP3A5* 1 for long-term survival in …
Worsening of Kidney Transplant Function During 2-Year Follow-up Is Associated With the Genetic Variants of CYP3A4, MDR1, and UGT1A9
E Hryniewiecka, J Zegarska, D Zochowska… - Transplantation …, 2020 - Elsevier
Abstract Background Calcineurin inhibitors (CNIs), tacrolimus and cyclosporine, undergo
pharmacokinetic processes. Enzymes and transport proteins found in various organs are …
pharmacokinetic processes. Enzymes and transport proteins found in various organs are …
Influence of CYP3A5 polymorphism on cydosporin A concentrations in the peripheral blood of hemopoietic stem cell transplant recipients
H Wang, P Mao, J Xie - Chinese Journal of Organ …, 1996 - pesquisa.bvsalud.org
Objective To explore the possibility of cytochrome P-450 3A5 (CYP3A5) genotype as a
major factor to guide individualized employment of cyclosporin A (CsA) through a …
major factor to guide individualized employment of cyclosporin A (CsA) through a …