Cyclosporine A (CsA) is a substrate of the multi‐drug efflux pump P‐glycoprotein (P‐gp)
encoded by ABCB1. Among the various single nucleotide polymorphisms (SNPs) of ABCB1 …

The aim of this study was to retrospectively evaluate the effect of polymorphisms in the
CYP3A4, CYP3A5 and ABCB1 genes on the dose-adjusted concentration and dose …

Cyclosporine, everolimus, and tacrolimus are the cornerstone of immunosuppressive
therapy in renal transplantation. These drugs are characterized by narrow therapeutic …

In patients who received allogeneic hematopoietic stem cell transplantation (HSCT), we
investigated the correlations between single nucleotide polymorphisms (SNPs) in genes that …

The aim of the study was to determine the impact of CYP3A5 mutation on the serum levels of
immunosuppressive drugs (tacrolimus and cyclosporine A), and on the occurrence of acute …

Abstract Background and Aims Calcineurin inhibitors, cyclosporine and tacrolimus have a
narrow therapeutic index and have wide intra-and inter individual pharmacokinetic …

AIM: To study the relationship be-tween the genetic polymorphism of CYP3A5 gene and the
blood concentration/dose (C/D) ratio of cyclospo-rine combined with calcium channel …

Background: Cyclosporine (CsA), which is used for graft-versus-host disease prophylaxis in
allogeneic hematopoietic stem cell transplant (allo-HSCT), has a narrow therapeutic range …

Objective To investigate the clinical efficacy of cyclosporine injection in subclinical or critical
treatment of renal transplant patients, and to establish an individualized dosage regimen of …

Objective To investigate the impact of CYP3A5 and ABCB1 polymorphisms on the initial
individualized treatment with tacrolimus (FK506) in renal transplant recipients during …