The intragraft vascularized bone marrow component plays a critical role in tolerance induction after reconstructive transplantation

CH Lin, MR Anggelia, HY Cheng, AYL Wang… - Cellular & molecular …, 2021 - nature.com
The role of the vascularized bone marrow component as a continuous source of donor-
derived hematopoietic stem cells that facilitate tolerance induction of vascularized composite …

[HTML][HTML] Cell therapy in vascularized composite allotransplantation

MR Anggelia, HY Cheng, PC Lai, YH Hsieh, CH Lin… - biomedical …, 2022 - Elsevier
Allograft rejection is one of the obstacles in achieving a successful vascularized composite
allotransplantation (VCA). Treatments of graft rejection with lifelong immunosuppression (IS) …

Clinical and preclinical tolerance protocols for vascularized composite allograft transplantation

JH Yang, AC Johnson, S Colakoglu… - Archives of plastic …, 2021 - thieme-connect.com
The field of vascularized composite allografts (VCAs) has undergone significant
advancement in recent decades, and VCAs are increasingly common and accepted in the …

Sensitization and desensitization in vascularized composite allotransplantation

D Moris, LC Cendales - Frontiers in immunology, 2021 - frontiersin.org
Vascularized composite allotransplantation (VCA) is a field under research and has
emerged as an alternative option for the repair of severe disfiguring defects that result from …

Ischemia-reperfusion injury in vascularized composite allotransplantation

EJ Caterson, J Lopez, M Medina… - Journal of …, 2013 - journals.lww.com
Vascularized composite allotransplantation may now be considered a viable treatment
option in patients with complex craniofacial and limb defects. However, the field is still in its …

Vascularized composite allografts and solid organ transplants: similarities and differences

A Weissenbacher, T Hautz, J Pratschke… - Current opinion in …, 2013 - journals.lww.com
We herein summarize the progress made in VCA in the last year with a focus on new clinical
immunosuppressive strategies and novel targets for immunosuppression and …

Accommodation and related conditions in vascularized composite allografts

JL Platt, CL Kaufman… - Current opinion in …, 2017 - journals.lww.com
The disrupted tissue in VCA and potential for repopulation by endothelial cells of the
recipient establish conditions that potentially decrease susceptibility to acute antibody …

[HTML][HTML] Spontaneous resolution of acute rejection and tolerance induction with IL-2 fusion protein in vascularized composite allotransplantation

R Jindal, J Unadkat, W Zhang, D Zhang, TW Ng… - American Journal of …, 2015 - Elsevier
Vascularized composite allotransplantation (VCA) has emerged as a treatment option for
treating nonlife-threatening conditions. Therefore, in order to make VCA a safe …

Differentiation between acute skin rejection in allotransplantation and T‐cell mediated skin inflammation based on gene expression analysis

D Wolfram, EM Morandi, N Eberhart… - BioMed Research …, 2015 - Wiley Online Library
Advances in microsurgical techniques and immunosuppressive medication have rendered
transplantation of vascularized composite allografts possible, when autologous tissue is …

Tolerance induction strategies in vascularized composite allotransplantation: mixed chimerism and novel developments

DA Leonard, DA McGrouther, JM Kurtz… - Journal of …, 2012 - Wiley Online Library
Since the start of the clinical vascularized composite allotransplantation (VCA) era over a
decade ago this field has witnessed significant developments in both basic and translational …