The lateral habenula and the serotonergic system

M Metzger, D Bueno, LB Lima - Pharmacology Biochemistry and Behavior, 2017 - Elsevier
The habenula (Hb) is an epithalamic structure differentiated into two nuclear complexes,
medial (MHb) and lateral habenula (LHb). After decades of relative neglect, interest in the …

Habenular connections with the dopaminergic and serotonergic system and their role in stress‐related psychiatric disorders

M Metzger, R Souza, LB Lima, D Bueno… - European Journal of …, 2021 - Wiley Online Library
The habenula (Hb) is a phylogenetically old epithalamic structure differentiated into two
nuclear complexes, the medial (MHb) and lateral habenula (LHb). After decades of search …

The lateral habenula in addiction and depression: an anatomical, synaptic and behavioral overview

S Lecca, FJ Meye, M Mameli - European Journal of …, 2014 - Wiley Online Library
The lateral habenula (LH b) is an epithalamic region with a crucial role in the regulation of
midbrain monoaminergic systems. Over the past few years a renewed interest in the LH b …

Circuits and functions of the lateral habenula in health and in disease

H Hu, Y Cui, Y Yang - Nature Reviews Neuroscience, 2020 - nature.com
The past decade has witnessed exponentially growing interest in the lateral habenula (LHb)
owing to new discoveries relating to its critical role in regulating negatively motivated …

[HTML][HTML] Understanding the habenula: A major node in circuits regulating emotion and motivation

JL Ables, K Park, I Ibañez–Tallon - Pharmacological research, 2023 - Elsevier
Over the last decade, the understanding of the habenula has rapidly advanced from being
an understudied brain area with the Latin name 'habena” meaning “little rein”, to being …

Can the lateral habenula crack the serotonin code?

A Tchenio, K Valentinova, M Mameli - Frontiers in synaptic …, 2016 - frontiersin.org
The lateral habenula (LHb) and the serotonergic system both contribute to motivational
states by encoding rewarding and aversive signals. Converging evidence suggests that …

Habenula: crossroad between the basal ganglia and the limbic system

O Hikosaka, SR Sesack, L Lecourtier… - Journal of …, 2008 - Soc Neuroscience
There is a growing awareness that emotion, motivation, and reward values are important
determinants of our behavior. The habenula is uniquely positioned both anatomically and …

The role of lateral habenula–dorsal raphe nucleus circuits in higher brain functions and psychiatric illness

H Zhao, BL Zhang, SJ Yang, B Rusak - Behavioural brain research, 2015 - Elsevier
Serotonergic neurons in the dorsal raphe nucleus (DRN) play an important role in regulation
of many physiological functions. The lateral nucleus of the habenular complex (LHb) is …

Dorsal raphe projection inhibits the excitatory inputs on lateral habenula and alleviates depressive behaviors in rats

H Zhang, K Li, HS Chen, SQ Gao, ZX Xia… - Brain Structure and …, 2018 - Springer
Hypofunction of the serotonergic (5-HT) system has close relationship with the symptoms in
major depressive disorders (MDD), however, the underlying neural circuitry mechanisms are …

5HT1B receptor-mediated pre-synaptic depression of excitatory inputs to the rat lateral habenula

EK Hwang, J Chung - Neuropharmacology, 2014 - Elsevier
Accumulating lines of evidence indicate that the lateral habenula (LHb), which reciprocally
interacts with raphe nuclei (RN), displays hyperactivity including synaptic potentiation of …