Cocaine abuse remains a devastating medical problem for our society. Current concepts
suggest that both hemorrhagic and ischemic stroke, particularly in young people, can result …

Stroke is the third most common cause of death in developed countries. In England and
Wales, 1000 people under the age of 30 have a stroke each year. Cocaine is the most …

Cocaine, especially in its alkaloidal or “crack” form, has been increasingly associated with
cerebrovascular disease. Before the crack epidemic, cocaine hydrochloride (HCl) was also …

OBJECTIVE: The authors reviewed the pathogenesis of cocaine-related cerebral ischemia,
appraised current knowledge of its sequelae, and assessed the role of putative therapeutic …

OBJECTIVE: An association between cocaine use and stroke has been reported, but few
studies have examined cocaine-related neurovascular disease using modern stroke …

Cocaine use is associated with ischemic stroke through unique mechanisms, including
reversible vasospasm, drug-induced arteritis, enhanced platelet aggregation …

Objectives: To determine the incidence of cocaine abuse in cases of fatal intracranial
hemorrhage and to examine potential pathophysiologic mechanisms. Design: Prospective …

Background Cocaine and other vasoactive substances are known causes of
cerebrovascular disease. Ictus during drug intake adversely affects outcome. Materials and …

This paper will examine how cerebral perfusion deficits in cocaine abusers may be a target
for pharmacotherapy. The review covers five areas:(1) cerebral ischemia and …

Background “Crack” cocaine (alkaloidal cocaine) induces ischemic stroke. However, the
mechanisms by which this occurs are not well documented in humans. We present pertinent …