We analyzed the frequency and relevance of mutations in the coding region of the androgen
receptor (AR) in genomic DNA extracted from 137 specimens of prostate cancer. The …

To investigate the structural abnormality of the androgen receptor (AR) in human prostate
cancers, exons BH encoding DNA-and hormone-binding domains were examined by single …

We screened human prostate cancer tissues for the presence of somatic mutations in the
hormone binding domain of the androgen receptor (AR) gene. Exons EH were amplified …

It is possible that structural changes of the androgen receptor (AR) contribute to the
insensitivity of prostatic carcinomas to endocrine therapy. We have isolated DNA from 58 …

Progression to androgen-independent growth of human prostate cancers may be mediated
by alterations in the structure and/or expression of the androgen receptor (AR) gene. To …

Prostate cancer is considered to be one of the most hormone‐dependent human
malignancies. As a key mediator of hormonal response, the androgen receptor (AR) is …

Essentially all prostatic carcinomas relapse to an androgen‐independent stage during
androgen ablation therapy. The underlying genetic changes are still unclear. Such changes …

The growth of prostate cancer is androgen responsive, and androgen receptor (AR) is
thought to play an important role in the development of this cancer. Recently, some reports …

Prostatic tissue specimens derived from transurethral resections of patients with metastatic
prostate cancer were analyzed for genetic alterations in the hormone-binding domain of the …

Structural changes of the androgen receptor (AR) may contribute to the development of
resistance to endocrine therapy in prostatic carcinoma. We have isolated AR cDNA …