The prion paradigm is increasingly invoked to explain the molecular pathogenesis of
neurodegenerative diseases involving the misfolding and aggregation of proteins other than …

Alzheimer's disease (AD) is the most common neurodegenerative disease in humans and
will pose a considerable challenge to healthcare systems in the coming years. Aggregation …

Since the discovery that prion diseases can be transmitted to experimental animals by
inoculation with afflicted brain matter, researchers have speculated that the brains of …

The aggregation of a soluble protein into insoluble, β-sheet rich amyloid fibrils is a defining
characteristic of many neurodegenerative diseases, including prion disorders. The prion …

Specific protein misfolding and aggregation are mechanisms underlying various
neurodegenerative diseases such as prion disease and Alzheimer's disease (AD). The …

Over the past four decades, prion diseases have received considerable research attention
owing to their potential to be transmitted within and across species as well as their …

Alzheimer disease (AD) has traditionally been thought to involve the misfolding and
aggregation of two different factors that contribute in parallel to pathogenesis: amyloid-β (Aβ) …

Many non-infectious neurodegenerative diseases are associated with the accumulation of
fibrillar proteins. These diseases all exhibit features that are reminiscent of those of …

Proteinopathies represent a group of diseases characterized by the unregulated misfolding
and aggregation of proteins. Accumulation of misfolded protein in the central nervous …

The deposition of misfolded proteins is the hallmark of the late-onset, rapidly progressive
and devastating neurodegenerative diseases including Alzheimer's disease, Parkinson's …