Dendrites and spines are the main neuronal structures receiving input from other neurons
and glial cells. Dendritic and spine number, size, and morphology are some of the crucial …

Multiple types of indirect evidence have been used to support theories of altered cortical
connectivity in autism spectrum disorders (ASD). In other developmental disorders reduced …

Dendritic spines are small actin-rich protrusions from neuronal dendrites that form the
postsynaptic part of most excitatory synapses. Changes in the shape and size of dendritic …

The activity-dependent structural and functional plasticity of dendritic spines has led to the
long-standing belief that these neuronal compartments are the subcellular sites of learning …

Dendrite morphology is pivotal for neural circuitry functioning. While the causative
relationship between small-scale dendrite morphological abnormalities (shape, density of …

Highlights•Genetic and functional studies have provided important evidence pointing toward
a central role for dendritic spines on the pathogenesis of neuropsychiatric conditions.•Many …

Dendritic spines are specialized structures on neuronal processes where the majority of
excitatory synapses are localized. Spines are highly dynamic, and their stabilization and …

Valproic acid (VPA) is a blocker of histone deacetylase widely used to treat epilepsy, bipolar
disorders, and migraine; its administration during pregnancy increases the risk of autism …

Autism spectrum disorder is a neurodevelopmental condition characterized by impaired
social communication and repetitive behaviors. Changes in the number of specific cell types …

Improving clinical tests are allowing us to more precisely classify autism spectrum disorders
and diagnose them at earlier ages. This raises the possibility of earlier and potentially more …