Despite decades of study, elucidation of the underlying etiology of complex developmental
disorders such as autism spectrum disorder (ASD), schizophrenia (SCZ), intellectual …

Although the neurobiology of autism has been studied for more than two decades, the
majority of these studies have examined brain structure 10, 20, or more years after the onset …

The majority of excitatory synaptic input in the brain is received by small bulbous actin-rich
protrusions residing on the dendrites of glutamatergic neurons. These dendritic spines are …

Context Autism often involves early brain overgrowth, including the prefrontal cortex (PFC).
Although prefrontal abnormality has been theorized to underlie some autistic symptoms, the …

Background Autism involves early brain overgrowth and dysfunction, which is most strongly
evident in the prefrontal cortex. As assessed on pathological analysis, an excess of neurons …

Objective: Evidence from prospective studies of high-risk infants suggests that early
symptoms of autism usually emerge late in the first or early in the second year of life after a …

Neuroimaging studies in autism spectrum disorders (ASDs) have provided inconsistent
evidence of cortical abnormality. This is probably due to the small sample sizes used in most …

Autism spectrum disorders (ASD) affect 1 in 68 children in the US according to the Centers
for Disease Control and Prevention (CDC). It is characterized by impairments in social …

Researchers have now identified many highly penetrant genetic risk factors for autism
spectrum disorder (ASD). Some of these genes encode synaptic proteins, lending support to …

The structural correlates of functional dysconnectivity in autism spectrum disorders (ASD)
have been seldom explored, despite the fact that altered functional connectivity is one of the …