Hypoxic–ischemic encephalopathy (HIE) and associated multiorgan injury are significant
causes of morbidity and mortality in term and near-term neonates. Therapeutic hypothermia …

There is now a strong evidence base supporting therapeutic hypothermia for infants with
moderate or severe neonatal hypoxic ischaemic encephalopathy. Experimental and clinical …

It remains controversial as to whether neonatal seizures have additional direct effects on the
developing brain separate from the severity of the underlying encephalopathy. Using data …

Aim Therapeutic hypothermia (TH), shown in developed countries to improve outcome in
infants with hypoxic-ischaemic encephalopathy (HIE), was introduced into standard care at …

Multiple randomized trials have provided strong evi-dence for the use of therapeutic
hypothermia initiated within 6 hours of age for infants≥ 36 weeks of gestation with hypoxic …

Background: Perinatal asphyxia and hypoxic-ischemic encephalopathy (HIE) represent
substantial sources of neonatal morbidity and mortality in low-and middle-income countries …

Background: Therapeutic hypothermia is an effective treatment for moderate or severe
hypoxic-ischaemic encephalopathy (HIE), with maximal neuroprotective benefit when …

Objective To determine whether moderate hypothermia after hypoxic-ischaemic
encephalopathy in neonates improves survival and neurological outcome at 18 months of …

Background Hypoxic ischemic encephalopathy (HIE) is a significant cause of mortality and
short-and long-term morbidities. Therapeutic hypothermia (TH) has been shown to be the …

Therapeutic hypothermia holds promise as a rescue neuroprotective strategy for hypoxic-
ischemic injury, but the incidence of severe neurologic sequelae with hypothermia is …