Role of ABCA1 in Cardiovascular Disease

J Wang, Q Xiao, L Wang, Y Wang, D Wang… - Journal of Personalized …, 2022 - mdpi.com
Cholesterol homeostasis plays a significant role in cardiovascular disease. Previous studies
have indicated that ATP-binding cassette transporter A1 (ABCA1) is one of the most …

Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis

LR Brunham, RR Singaraja, MN Duong… - … , and vascular biology, 2009 - Am Heart Assoc
Objective—The ATP-binding cassette transporter, subfamily A, member 1 (ABCA1) plays a
key role in HDL cholesterol metabolism. However, the role of ABCA1 in modulating …

The cell cholesterol exporter ABCA1 as a protector from cardiovascular disease and diabetes

C Tang, JF Oram - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2009 - Elsevier
ATP-binding cassette transporter A1 (ABCA1) is an integral cell membrane protein that
exports cholesterol from cells and suppresses macrophage inflammation. ABCA1 exports …

The target of regulating the ATP-binding cassette A1 protein (ABCA1): promoting ABCA1-mediated cholesterol efflux in different cells

CX Huang, YL Zhang - Current Pharmaceutical Biotechnology, 2013 - ingentaconnect.com
The ATP-binding cassette A1 (ABCA1) transporter plays a major role in the efflux of lipids by
mediating the cellular transport of phospholipids and cholesterol to lipid-poor/lipid-free …

ATP-binding cassette transporter A1: key player in cardiovascular and metabolic disease at local and systemic level

M Van Eck - Current Opinion in Lipidology, 2014 - journals.lww.com
Recent studies underscore the importance of ABCA1 in the prevention of cardiovascular and
metabolic diseases. Furthermore, the discovery of the extensive regulation of ABCA1 …

Regulation of ABCA1 functions by signaling pathways

Y Liu, C Tang - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2012 - Elsevier
ATP-binding cassette transporter A1 (ABCA1) is an integral cell membrane protein that
protects cardiovascular disease by at least two mechanisms: by export of excess cholesterol …

The role of the ATP-binding cassette A1 (ABCA1) in human disease

L Jacobo-Albavera, M Domínguez-Pérez… - International journal of …, 2021 - mdpi.com
Cholesterol homeostasis is essential in normal physiology of all cells. One of several
proteins involved in cholesterol homeostasis is the ATP-binding cassette transporter A1 …

ABCA8 regulates cholesterol efflux and high-density lipoprotein cholesterol levels

L Trigueros-Motos, JC van Capelleveen… - … , and vascular biology, 2017 - Am Heart Assoc
Objective—High-density lipoproteins (HDL) are considered to protect against
atherosclerosis in part by facilitating the removal of cholesterol from peripheral tissues …

ATP binding cassette transporter A1-key roles in cellular lipid transport and atherosclerosis

N Srivastava - Molecular and cellular biochemistry, 2002 - Springer
ATP-binding cassette transporter A1 (ABCA1) was recently recognized as the mutant
molecule responsible for Tangier disease with low HDL levels, accumulation of cholesteryl …

Posttranscriptional Regulation of ATP-Binding Cassette Transporter A1 in Lipid Metabolism

Y Lv, K Yin, Y Fu, D Zhang, W Chen, C Tang - DNA and cell biology, 2013 - liebertpub.com
Aim: Several lines of evidence have shown that posttranscriptional regulations play an
important role in the modulation of ATP-binding cassette transporter A1 (ABCA1) expression …