Celecoxib vs indomethacin and acute gastric lesions in rats
OM Laudanno, JM Esnarriaga, JA Cesolari… - Medicina, 2000 - europepmc.org
In 5 random groups of Wistar rats (n= 15 for each group), ulcerogenic doses of NSAIDs COX-
1-COX-2 inhibitors such as indomethacin were compared with Celecoxib (COX-2 inhibitor); …
1-COX-2 inhibitors such as indomethacin were compared with Celecoxib (COX-2 inhibitor); …
Gastrointestinal damage induced by celecoxib and rofecoxib in rats
OM Laudanno, JA Cesolari, J Esnarriaga… - Digestive diseases and …, 2001 - Springer
Five experimental models were developed in different groups of Wistar rats (N= 15) to study
selective COX-2-inhibitor NSAIDs such as celecoxib and rofecoxib, as follows:(1) dose …
selective COX-2-inhibitor NSAIDs such as celecoxib and rofecoxib, as follows:(1) dose …
Effects of celecoxib on acid-challenged gastric mucosa of rats: comparison with metamizol and piroxicam
B Berenguer, CA De la Lastra, V Motilva… - Digestive diseases and …, 2004 - Springer
Selective COX-2 inhibitors have been shown to produce fewer gastrointestinal adverse
reactionsthan classical NSAIDs. Nevertheless, these new agents may worsen and delay the …
reactionsthan classical NSAIDs. Nevertheless, these new agents may worsen and delay the …
Gastrointestinal damage induced by celecoxib and rofecoxib in rats
OM Laudanno, JA Cesolari, J Esnarriaga… - Acta …, 2000 - europepmc.org
Conclusion Dose-dependent administration of celecoxib and rofecoxib as COX-2 inhibitors
and non-COX-1 inhibitors, respectively, did not produce toxic injuries on healthy …
and non-COX-1 inhibitors, respectively, did not produce toxic injuries on healthy …
Mechanism of action of celecoxib on normal and acid-challenged gastric mucosa
N Dutta, P Sarotra, S Gupta, R Aggarwal… - Experimental and …, 2009 - Elsevier
Selective COX-2 inhibitor, celecoxib, delays the healing of gastric ulcers by inhibiting
prostaglandins synthesis. Therefore, the effect of celecoxib on normal and acid-challenged …
prostaglandins synthesis. Therefore, the effect of celecoxib on normal and acid-challenged …
The effects of some nonsteroidal anti-inflammatory drugs on experimental induced gastric ulcers in rats
OS Batu, K Erol - Inflammopharmacology, 2007 - Springer
Celecoxib is a frequently used nonsteroidal anti-inflammatory drug (NSAID) in the treatment
of rheumatoid arthritis and osteoarthritis. It selectively inhibits cyclooxygenase II (COX-2) …
of rheumatoid arthritis and osteoarthritis. It selectively inhibits cyclooxygenase II (COX-2) …
Gastric effects of the selective cyclooxygenase-2 inhibitor, celecoxib, in the rat
G Coppelli, E Guaita, S Spaggiari, G Coruzzi - Digestive and liver disease, 2004 - Elsevier
Background. Recent studies have revealed that cyclooxygenase-2 is involved in the
protection of the damaged gastric mucosa, mediating, in particular, the acceleration of ulcer …
protection of the damaged gastric mucosa, mediating, in particular, the acceleration of ulcer …
Pharmacological profile of celecoxib, a specific cyclooxygenase-2 inhibitor
T Yoshino, A Kimoto, S Kobayashi… - …, 2005 - thieme-connect.com
The pharmacological profile of celecoxib (CAS 169590-42-5, SC-58635), a specific
cyclooxygenase-2 (COX-2) inhibitor, was investigated. Celecoxib inhibited COX-2-mediated …
cyclooxygenase-2 (COX-2) inhibitor, was investigated. Celecoxib inhibited COX-2-mediated …
Experimental study of the safety of the selective COX‐2 inhibitor, celecoxib, for gastric mucosa
JT LI, ZS LI, XB ZHAN, ZM CUI… - Chinese Journal of …, 2003 - Wiley Online Library
OBJECTIVE: To compare the gastric mucosal damage induced by a COX‐2 inhibitor,
celecoxib, and a conventional NSAID, indomethacin. METHODS: A rat model of NSAID …
celecoxib, and a conventional NSAID, indomethacin. METHODS: A rat model of NSAID …
Comparison of the intestinal toxicity of celecoxib, a selective COX-2 inhibitor, and indomethacin in the experimental rat
JA Tibble, G Sigthorsson, R Foster… - Scandinavian journal of …, 2000 - Taylor & Francis
Background: It is suggested that the gastrointestinal toxicity of conventional non-steroid anti-
inflammatory drugs (NSAIDs) is due to a'topical'effect in addition to inhibition of the mucosal …
inflammatory drugs (NSAIDs) is due to a'topical'effect in addition to inhibition of the mucosal …